We have compared the rate and extent of adhesion of various types of mouse tumor cells to endothelial cells derived from different organ sources. Our panel of tumors has included sarcoma, bladder carcinoma, glioma, teratoma, hepatoma, endothelioma, mammary adenocarcinoma, and lymphoma cells. Endothelial cell monolayers have included murine microvascular endothelial cells from ovary, brain, lung...

KAPosI multiple idiopathic haemorrhagic sarcoma is a peculiar condition which cannot be accurately classified (Reese, 1963). It was regarded by Kaposi (1872) as a cutaneous sarcoma affecting the blood vessels; by Ewing (1922) as an infectious granuloma; by Pautrier and Diss (1928) as originating from nerve tissue; and by D6rffel (1932) as arising from the reticulo-endothelial system, the lesion...

The molecular mechanisms underlying lymphocyte extravasation remain poorly characterized. We have recently identified junctional adhesion molecule-2 (JAM-2), and have shown that antibodies to JAM-2 stain high endothelial venules (HEVs) within lymph nodes and Peyer patches of adult mice. Here we show that mouse lymphocytes migrate in greater numbers across monolayers of endothelioma cells transf...

When stimulated by a filterable agent of leukosis of chickens (Strain 2), endothelium may undergo seemingly unrestricted growth. These neoplasms of endothelium are usually unaccompanied by the formation of blood cells. Occasionally they produce hemocytoblasts, discharged like those of the normal marrow into vascular channels as also myelocytes about the vessels. The same agent that stimulates e...

Sheehan (1930) when describing a malignant liver tumour in a young child, first brought together a number of such tumours previously described under a variety of names, such as 'sarcoma', 'endothelioma' or 'angeiosarcoma', and pointed out that they were probably all derived from rests of undifferentiated mesenchymal cells and were in fact embryonic growths. The tumour he described consisted lar...