Introduction The anticancer properties of fluoroquinolones and the high concentrations they achieve in urine may help bladder cancer therapy. This study aimed to analyze 4 as potential candidates for supportive treatment cancer. Methods Comparative analyses were performed on cytotoxic effects norfloxacin, enrofloxacin, moxifloxacin, ofloxacin normal urothelial cell lines. In 2D culture, evaluat...

Sir, Bartonella henselae are fastidious, facultative intracellular bacilli that can cause bacteraemia, endocarditis, cat-scratch disease in immunocompetent patients, and bacillary angiomatosis and peliosis hepatitis in immunocompromised patients. There are a limited number of studies that have addressed the antibiotic treatment of cats infected with B. henselae. Azithromycin, a macrolide compou...

Sir, Fluoroquinolones are broad-spectrum antimicrobial agents that are effective against Gram-positive and Gram-negative bacteria. Enrofloxacin, the first fluoroquinolone approved for veterinary use, is still commonly used in veterinary practice to treat infections in food-producing, pet and companion animals, caused by a wide variety of bacterial pathogens including methicillinresistant Staphy...

Using Bartonella henselae isolates from cats and a human, the activity of pradofloxacin was compared with those of enrofloxacin and azithromycin. By Etest and disc diffusion assay, pradofloxacin showed greater antimicrobial activity than did other antibiotics. We conclude that pradofloxacin may prove useful for the treatment of B. henselae infections.

Fifty strains of Staphylococcus intermedius were isolated from different pathological specimens originating from dogs during a six-month period. Antimicrobial susceptibility patterns against three fluoroquinolones were obtained on 50 Staphylococcus intermedius strains. In vitro antimicrobial susceptibility testing was performed employing the disk diffusion method (Kirby-Bauer). The sensitivity ...

The in vitro activities of four fluoroquinolone compounds were tested against 92 Escherichia coli strains of ovine and caprine origin under aerobic and anaerobic incubation conditions. The four fluoroquinolones proved to be highly effective against the E. coli isolates tested. When bacteria were cultured anaerobically, at least fourfold increases in the MICs of enoxacin for the strains occurred...

We compared the values of the minimum inhibitory concentration (MIC) and mutant prevention concentration (MPC) values of three antimicrobial agents for 72 bovine isolates of Pasteurella multocida, 80 swine isolates of P. multocida, 80 bovine isolates of Escherichia coli, 80 swine isolates of E. coli, and 80 isolates of Staphylococcus aureus from bovine mastitis. The ratio of MIC90 /MPC90 which ...