Abstract Background Enterocytozoon hepatopenaei (EHP) is an enteric pathogen that affects Penaeus vannamei and monodon shrimp in many SE Asian countries. In the western hemisphere, EHP was reported for first time 2016 farmed P. Venezuela. Anecdotal evidence suggests more prevalent grow-out ponds where salinity high (> 15 parts per thousand (ppt)) compared to with low salinities (< 5 ppt)....