Early detection of Alzheimer's disease (AD) has been challenging as current biomarkers are invasive and costly. Strong predictors of future AD diagnosis include lower volume of the hippocampus and entorhinal cortex, as well as the ɛ4 allele of the Apolipoprotein E gene (APOE) gene. Therefore, studying functions that are critically mediated by the hippocampus and entorhinal cortex, such as spati...

Astrocytes represent the major glial cell population within the central nervous system. In order to elucidate the function of astrocytes under physiological conditions and during the course of neurological disease, astrocytic gene expression profiling is necessary. However, since astrocytes form an intimately connected network with neurons and other cell types in the brain, gene expression anal...

The expression of the immediate-early gene c-fos was used to compare networks of activity associated with recency memory (temporal order memory) and recognition memory. In Experiment 1, rats were first familiarized with sets of objects and then given pairs of different, familiar objects to explore. For the recency test group, each object in a pair was separated by 110 min in the time between th...

p. 21 1. Function and Dysfunction of the Entorhinal cortex p. 23 1.1 Anatomy and Organisation of the EC p. 23 1.1.1 Subdivisions of the EC p. 23 1.1.2 Lamination and Cytoarchitecture p. 25 1.1.3 Differences and Similarities in Lamination between the LEC and MEC p. 27 1.1.4 Entorhinal-Hippocampal Connections p. 28 1.1.5 Entorhinal-Cortical and Entorhinal-Subcortical Connections p. 30 1.1.5.1 Ent...

Hippocampal place cells are a model system of how the brain constructs cognitive representations and of how these representations support complex behavior, learning, and memory. There is, however, a lack of detailed knowledge about the properties of hippocampal afferents. We recorded multiple single units from the hippocampus and the medial and lateral entorhinal areas of behaving rats. Althoug...