Hypertension, defined as a systolic/diastolic blood pressure of 140/90 mmHg or greater, is estimated to carry a three-fold increased risk of developing cardiovascular diseases (CVDs). Evidence from genome-wide association studies has identified an association between blood pressure and the gene encoding the folate-metabolising enzyme, methylenetetrahydrofolate reductase (MTHFR). Recent meta-ana...

aim : to investigate association between mthfr gene polymorphism with colorectal cancer. background : the enzyme 5,10-methylene-tetrahydrofolate reductase (mthfr) is linked to dna methylation, synthesis and repair. one of the most important polymorphisms that has been identified in the mthfr gene is c677t. the single nucleotide polymorphism c677t has been found to be associated with decreased e...

BACKGROUND: Iodothyronine deiodinase (DIO) is an enzyme that regulates thyroid hormone activity. DIO consists of three types: 1 (D1), 2 (D2), and 3 (D3). D2 a gene plays important role in regulation the biochemistry several tissues. also production triiodothyronine controlling signals. This study measured observation about 15% normal population show polymorphism (Thr92Ala) potentially affects a...

In silico 16S ribosomal RNA gene-based restriction enzyme approach is a computer-simulated polymerase chain reaction-restriction fragment length polymorphism analysis method, namely customizable in sequence evaluation for sites. The purpose of this study was to identify lactic acid bacteria using gene (16S polymorphism). An investigation conducted detect species-specific molecular markers diffe...

CONTEXT Alterations of the renin-angiotensin system have been implicated in the pathogenesis of various diseases. The angiotensin converting enzyme is a key enzyme in the renin-angiotensin system. A deletion polymorphism of a 287-bp fragment of intron 16 of the angiotensin converting enzyme gene allele results in higher levels of circulating enzyme. ACE deletion genotype has been linked to hear...

Acute Myeloid Leukemia (AML) and Chronic (CML) are life-threatening hematological neoplasms characterized by an uncontrolled proliferation of myeloid progenitors. The phase I metabolism response, which metabolizes xenobiotics endogenous exogenous DNA-reactive chemical compounds that may cause genotoxicity raise the risk AML CML, is catalyzed cytochrome P450 (CYP) enzyme. current study aimed to ...

Some evidence suggests that a variety of genetic factors contributed in pathogenesis of the preeclampsia. The aim of this study was to assess the association between the angiotensin-converting enzyme (ACE) I/D and angiotensin II type1 receptor A1166C polymorphisms with preeclampsia. This study was performed in 125 preeclamptic pregnant women and 132 controls. The I/D Polymorphism of the ACE gen...

background: the study of the association between genotype and phenotype is of great importance for the prediction of many diseases and pathophysiological conditions. the relationship between angiotensin-converting enzyme (ace) gene insertion/ deletion (i/d) polymorphism and pathological processes such as coronary artery disease (cad) has been investigated previously with discordant results. thi...

human serum paraoxonase (pon) associated with high density lipoprotein (hdl) , has been postulated to have a role in protecting low-density lipoprotein (ldl) against oxidative damage, which has led to the proposal that pon is an anti-atherogenic and anti-inflammatory enzyme. it has genetic polymorphism at the 191 (r ->q) and two alloenzymes a and b and three phenotypes a, b, and ab. we examined...

BACKGROUND AND OBJECTIVES To investigate coagulase gene polymorphism of MRSA and MSSA isolates from Shiraz teaching hospitals from 2011 to 2012. MATERIALS AND METHODS A total of 302 isolates of Staphylococcus aureus were collected from clinical specimens in three major teaching hospitals and confirmed on the basis of morphological characteristics and biochemical tests. The isolates were subje...