The hyperglycemic effects of epinephrine (Epi) are established; however, the modulation of Epi-stimulated endogenous glucose production (EGP) by glucose and insulin in vivo in humans is less clear. Our aim was to determine the effect of exogenously increased plasma Epi concentrations on insulin and glucose dynamics. In six normal control subjects, we used the labeled intravenous glucose toleran...

position 6,1-4) the preparation of 7-epi-aminocephalosporanic 'acid (7a-ACA) has thus far not been reported. Some 7-epi-cephalosporins have been prepared by base-catalyzed epimerization of cephalosporin sulfoxidesu or acidcatalyzed ring expansion of 6-epi-penicillins.e) Both procedures, however, are not convenient for the preparation of 7-epi-cephalosporin derivatives. We wish to report the direct

INTRODUCTION – High resolution Diffusion Tensor Imaging (DTI) has been challenging for several reasons. Perhaps the major obstacle is due to the random phase effects that change between successive shots and pixel-by-pixel misregistration caused by patient motion. In addition, DTI images acquired with EPI are typically hampered by geometric distortion, blurring, and – in the case of multi-shot E...

Epibatidine (EPI), a potent cholinergic agonist, disrupts acetylcholine-dependent spontaneous retinal activity. Early patch-clamp recordings in juvenile ferrets suggested that EPI blocks all retinal ganglion cell (RGC) action potentials when applied to the retina. In contrast, recent experiments on the developing mouse that relied on multielectrode array (MEA) recordings reported that EPI appli...

Anthracyclines are effective genotoxic anticancer drugs for treating human malignancies; however, their clinical use is limited by tumor resistance and severe cardiotoxicity (e.g., congestive heart failure). Epirubicin (EPI) is less cardiotoxic compared with other canonical anthracyclines (e.g., doxorubicin). This has been attributed to its unique glucuronidation detoxification pathway. EPI is ...

Upon colonization in the host gastrointestinal tract, the enteric bacterial pathogen Campylobacter jejuni is exposed to a variety of signaling molecules including the catecholamine hormones epinephrine (Epi) and norepinephrine (NE). NE has been observed to stimulate the growth and potentially enhance the pathogenicity of C. jejuni. However, the underlying mechanisms are still largely unknown. I...