BACKGROUND Three longitudinal studies of cancer incidence in varied populations of World Trade Center responders have been conducted. METHODS We compared the design and results of the three studies. RESULTS Separate analyses of these cohorts revealed excess cancer incidence in responders for all cancers combined and for cancers of the thyroid and prostate. Methodological dissimilarities inc...

BACKGROUND Food preferences vary substantially among adults and children. Twin studies have established that genes and aspects of the shared family environment both play important roles in shaping children's food preferences. The transition from childhood to adulthood is characterized by large gains in independence, but the relative influences of genes and the environment on food preferences in...

OBJECTIVE A genetic risk score (GRS) for coronary artery disease has recently been shown to be independent of family history (FHx) in predicting future cardiovascular events. We sought to determine whether the presence of these risk factors, either individually or together, was associated with a higher burden of angiographic coronary artery disease. APPROACH AND RESULTS We included 763 patien...

Epidemiologic studies suggest that higher polyphenol intake from fruits and vegetables is associated with decreased risk for cardiovascular disease. The mechanisms explaining this observation remain unclear. This review summarizes data suggesting that flavonoids improve endothelial function and inhibit platelet aggregation in humans. The vascular endothelium is a critical regulator of vascular ...

conclusion we conclude that coronary calcium scoring provided useful information in the management of patients. in cacs less than 100, it has a npv of 87% in excluding significant stenosis in patients with the risk of cad but it does not have enough diagnostic accuracy for surely excluding coronary stenosis, so we should perform a combination of cacs and coronary ct angiography for patients. re...

BACKGROUND As people in middle and lower income countries live longer, more people become sick, disabled, and frail and the demand for family caregiving grows. Thailand faces such challenges. This study investigates the relationship between caregiving and mental health among workers drawn from a large longitudinal cohort of Thai adults. METHODS Participants were drawn from the Thai Health-Ris...

RECENTLY a number of epidemiologic studies1-6 have been published concerning the possible causes of the relative immunity of various classes and groups of non-American men against overt coronary artery disease. Since a low-fat intake was thought to be a trait common to all of these groups, it was concluded that this dietary habit was chiefly responsible for the observed relative infrequency of ...