Ovarian cancer is complex disease composed of different histological grades and types. However, the underlying molecular mechanisms involved in the development of different phenotypes remain largely unknown. Epidemiological studies identified multiple exogenous and endogenous risk factors for ovarian cancer development. Among them, an inflammatory stromal microenvironment seems to play a critic...

A fatal case of vaccinia necrosum treated with antivaccinial gamma globulin and N-methyl isatin beta-thiosemicarbazone (33T57) is described. Histological abnormalities found at necropsy included intranuclear as well as cytoplasmic inclusion bodies, absence of lymphoid germinal centres, grey hepatization, and bronchiolar epithelial hyperplasia. Virus titres were highest in the original skin lesi...

BACKGROUND We present the potential of inclusion bodies (IBs) as a protein delivery method for polymeric filamentous proteins. We used as cell factory a strain of E. coli, a conventional host organism, and keratin 14 (K14) as an example of a complex protein. Keratins build the intermediate filament cytoskeleton of all epithelial cells. In order to build filaments, monomeric K14 needs first to d...

F-18 FDG PET/CT provides an accurate staging and post-therapeutic evaluation of melanoma based on high metabolic characteristics of its primary and secondary lesions. This functional imaging modality may, however, detect coexisting benign lesions of inflammatory or infectious origin mimicking malignancy thus interfering with the staging of cancer. The authors present a case of ruptured epiderma...

Received February 2008 Accepted July 2008 INTRODUCTION Congenital epidermoid cysts may form along the median raphe of the penis on the penile shaft or the glans.(1) Epidermal inclusion cysts may develop after circumcision, repair of hypospadias, or other types of penile surgery when islands of epithelium are left behind in the subcutaneous tissue. These cystic lesions should be treated by simpl...

About 100 million women are estimated to be circumcised globally. Various rates of complications have been encountered, especially after circumcision, such as bleeding, infection, shock, menstrual irregularity, difficulty in urination or common urinary tract infections, inguinal pain, difficulty in sexual intercourse, and genital circumcision scar especially at the vulvar region, and cystic or ...

In a recent statistical survey of 2,756 cases of non-gonococcal urethritis examined at the Urological Clinic of the Faculty of Medicine in Paris (Hopital Cochin), inclusion bodies were found in 84, i.e., an average of about 3 per cent. In patients suffering from the urethro-conjunctivo-synovial syndrome, we have found, as previously reported by Harkness (1945), inclusion bodies in scrapings fro...

the komshecheh barite-fluorite deposit is the product of epigenetic hydrothermal mineralizationin dolomitized limestone of middle triassic age. the deposit is structurally and lithologically controlled andoccurs predominantly as bedded stratabound replacement sheets, although the veins and solution-collapsebreccias constitute important modes of occurrence. brecciation, dolomitization, silicific...

abstractepidermal inclusion cysts are uncommon in the breast, but the consequences can besevere when these cysts occur in the breast parenchyma. here, we report two suchcases. the patient in case 1 was an 37-year-old woman with a 3-cm palpable mass inthe right breast. mammography revealed a round and smoothly outlined mass, whichindicated a benign tumor, and sonography showed an irregularly sha...

Cyclodextrins are natural macrocyclic oligosaccharides able to form inclusion complexes with a wide variety of guests, affecting their physicochemical and pharmaceutical properties. In order to obtain an improvement of the bioavailability and solubility of 5-fluorouracil, a pyrimidine analogue used as chemotherapeutic agent in the treatment of the colon, liver, and stomac cancers, the drug was ...