We examined the effects of the neurosteroid pregnenolone sulfate (PS) on GABA(A) receptor-mediated synaptic currents and currents elicited by rapid applications of GABA onto nucleated outside-out patches in cultured postnatal rat hippocampal neurons. At 10 microm, PS significantly depressed peak responses and accelerated the decay of evoked inhibitory synaptic currents. In nucleated outside-out...

We have examined the kinetics of closure of sodium channels using single-channel recordings in cell-attached and excised membrane patches of rabbit ventricular myocytes. Sodium-channel closure was dependent on membrane potential. The closing rate initially decreased with depolarization. The rate then passed through a minimum and increased at strongly depolarized potentials. We attempted to dete...

The study examined whether the benefit of deactivating stimulation sites estimated to have broad neural excitation was attributed to improved spectral resolution in cochlear implant users. The subjects' spatial neural excitation pattern was estimated by measuring low-rate detection thresholds across the array [see Zhou (2016). PLoS One 11, e0165476]. Spectral resolution, as assessed by spectral...

Arterial baroreceptors in the carotid sinus and aortic arch regions reflexly regulate heart rate and peripheral vascular responses during changes in arterial pressure. The relative influence of these two arterial baroreflex pathways on the control of these autonomic responses is debatable. Recent studies in our laboratory demonstrate that the aortic baroreflex produces substantial and sustained...

OBJECTIVE To compare the effects of intravenously administered long-acting insulin analog glargine and regular human insulin on activation and deactivation of endogenous glucose output (EGO) and peripheral glucose uptake. RESEARCH DESIGN AND METHODS In this single-center, randomized, double-blind, crossover euglycemic glucose clamp study, 15 healthy male volunteers (aged 27 +/- 4 years, BMI 2...

Composite magnetic catalysts containing different amounts of sulfated titania (33–50 wt %) have been prepared by means high energy ball-milling between TiO2 and NiFe2O4. The characterized with N2 adsorption/desorption isotherms, XRD, temperature programmed oxidation (TPO) vibrating sample magnetometer (VSM). catalytic activity was measured in the reaction aniline 4-phenylbutyric acid continuous...

Simulations with a model of left ventricular pressure generation consisting of time varying Elastance, Resistance, Series-Elastance and Deactivation were fitted to pressure curves measured in the isolated rabbit ventricle. For constant ejection flows a fit with a RMS error of 2.78 mmHg was obtained provided that deactivation was actually incorporated in the model. Deactivation was assumed to de...