Recent sequencing efforts in melanoma have elucidated many previously unknown molecular pathways and biological mechanisms involved in melanoma development and progression and have yielded a number of promising targets for molecular therapy. As sequencing technologies have become more sophisticated and have revealed an ever-increasing complexity of the genetic landscape of melanoma, it has beco...

s | 35 schizophrenia. High fat, very low carbohydrate ketogenic diet (KD) induces adaptive changes in brain energy metabolism through bypassing impaired metabolic pathways and increasing energy reserves. We hypothesised that KD may have beneficial effects in schizophrenia. To test this hypothesis we studied the effects of KD in NMDA receptor hypofunction models of schizophrenia by measuring a v...

s | 35 schizophrenia. High fat, very low carbohydrate ketogenic diet (KD) induces adaptive changes in brain energy metabolism through bypassing impaired metabolic pathways and increasing energy reserves. We hypothesised that KD may have beneficial effects in schizophrenia. To test this hypothesis we studied the effects of KD in NMDA receptor hypofunction models of schizophrenia by measuring a v...

Purpose: This study was designed to investigate the biological and therapeutic significance of ERBB1, ERBB2, ERBB3, and ERBB4 in childhood ependymoma. Experimental Design: The expression frequency and clinical significance of ERBB1–4 was analyzed in a large cohort of pediatric ependymoma (n 121) using immunohistochemistry, Western blotting, and reverse transcriptionPCR analysis. Histological ma...

Malignant melanoma is a life-threatening skin cancer increasingly diagnosed in the western world. In advanced disease the prognosis is grave. Growth and metastasis formation in melanomas are regulated by a network of cytokines, cytokine-receptors, and adhesion molecules. However, little is known about surface antigens and target expression profiles in human melanomas. We examined the cell surfa...

BACKGROUND Nowadays, oocytes and embryos vitrification has become a routine technique. Based on clinical judgment, re-vitrification maybe required. But little is known about re-vitrification impact on genes expression. OBJECTIVE The impact of re-vitrification on apoptotic and implanting genes, Bax, Bcl-2 and ErbB4, at compaction stage embryos were evaluated in this study. MATERIALS AND METH...

BACKGROUND This study aimed to identify the potential molecular network associated with colon cancer metastasis. METHODS A gene expression profile dataset (GSE40367) downloaded from Gene Expression Omnibus was used to identify and compare differentially expressed genes (DEGs) between primary colon adenocarcinoma tissues and matched tissue samples of liver metastases of colon adenocarcinoma. A...

PURPOSE This study was designed to investigate the biological and therapeutic significance of ERBB1, ERBB2, ERBB3, and ERBB4 in childhood ependymoma. EXPERIMENTAL DESIGN The expression frequency and clinical significance of ERBB1-4 was analyzed in a large cohort of pediatric ependymoma (n = 121) using immunohistochemistry, Western blotting, and reverse transcription-PCR analysis. Histological...