Amaç: Beta blokerlerin nonkardiyak cerrahiye giden hastalarda perioperatif kardiyak hasarı önleyebileceği gösterilmiştir. Çalışmamızın amacı; kalp dışı operasyona ve olay gelişimi açısından orta-yüksek riskli esmolol infüzyonu kullanımının, hemodinamiye, tüketilen inhalasyon ajanı narkotik madde miktarına, postoperatif analjezik ilaç miktarına yan etkilere olan etkisini araştırmaktır. Materyal ...

Sodium dodecyl sulfate (SDS) was introduced as an esterase inhibitor in the determination of two extremely labile, ultrashort-acting beta-blockers-esmolol and flumolol--in whole blood. SDS was much more efficient than previously used agents in preventing hydrolysis. The assay comprises solvent extraction, perfluoroacylation, and capillary gas-chromatography with electron-capture detection. The ...

Ultrasound examinations of the heart and major peripheral arteries have been performed as separate procedures; both potentially limited by suboptimal views in certain subjects and the inability to obtain ideal pictures of particular intracardiac structures. Transvenous ultrasound may offer new advantages in certain areas, we therefore studied six adult baboons using a single-plane 5.5-10 MHz tr...

BACKGROUND T-wave alternans (TWA) is an important noninvasive measure of ventricular arrhythmia vulnerability. This study tested the hypothesis that the autonomic nervous system influences TWA measurement in high-risk subjects with coronary artery disease. METHODS AND RESULTS T-wave alternans was measured in 60 patients with coronary artery disease, left ventricular dysfunction, and inducible...

OBJECTIVE It was investigated whether pharmacologically induced changes in right ventricular contractility can be detected by a so-called "single-beat" method that does not require preload reduction. DESIGN Prospective animal research. SETTING Laboratory at a large university medical center. SUBJECTS Eight anesthetized pigs. INTERVENTIONS End-systolic elastance values obtained by a rece...

Although rotational parameters by speckle tracking echocardiography (STE) have been previously compared to sonomicrometry and cardiac magnetic resonance imaging, few have examined the relationship between left ventricular (LV) rotational mechanics and intraventricular measures of load-independent contractility, LV stiffness, or ventriculoarterial coupling. The aim of this study was to compare t...

The role of the cardiac sympathetic nerve activity in various cardiac diseases is typically evaluated using β-adrenergic receptor antagonists. However, these antagonists induce global denervation effects not only in the cardiovascular system, but also in the brain and kidney. The objective of this study was to detect the electrophysiological property changes due to 8 days of cardiac sympathetic...

BACKGROUND We investigated the hypothesis that manipulation of cardiac output (CO) with esmolol (Es) or ephedrine (E) affects the onset time of rocuronium. METHODS Following anesthesia induction, 33 patients received E (70 micro g kg-1), Es (500 micro g kg-1) or placebo (P) 30 s before rocuronium (0.6 mg kg-1) administration. Cardiac output was measured non-invasively after intubation every 3...