BACKGROUND Treatment of systemic-onset juvenile idiopathic arthritis (So-JIA) is challenging, and the efficacy of injectable recombinant human tumor necrosis factor type 1 receptor-antibody fusion protein (etanercept) on So-JIA has been controversial. METHODS We retrospectively studied 12 patients with refractory systemic juvenile arthritis treated with etanercept at our hospital in the past ...

BACKGROUND Concerns have been raised about a potential link between the use of TNF inhibitors and development of malignancy in the pediatric population. We examined the worldwide experience of etanercept use in pediatric patients and the occurrence of malignancies as reported from clinical trials, registry studies, post-marketing surveillance, and published scientific literature. METHODS All ...

OBJECTIVE B cells have been shown to play an important role in the pathogenesis of rheumatoid arthritis and juvenile idiopathic arthritis (JIA). Current treatments include the disease-modifying antirheumatic drugs methotrexate (MTX) and tumor necrosis factor α inhibition with etanercept. This study was undertaken to determine how these drugs influence the B cell compartment in patients with JIA...

in reducing prednisolone to 5 mg (original maintenance dosage) without any recurrences (Fig. 1). To date, there has been no flare-up of scleritis for 12 months. According to previous reports, TNFa may play a role in uveitis and scleritis in patients with RA (Di Girolamo et al. 1997; Braun et al. 2005; Smith et al. 2005), but anecdotal reports paradoxically implicated etanercept as a cause of uv...

Results Of the 16 patients, 10 were treated with etanercept (62.5%), 1 with adalimumab (6.25%), and 5 (31.2%) with infliximab. Notably, two cases of uveitis were associated with use of etanercept. In 5 patients (31.2%) the antiTNF was changed because of lack of efficacy and/or side effects to another one (in 4/5 adalimumab). Ten patients had a complicated uveitis (cataract in 5). The number of ...

Methods The study enrolled 54 pediatric patients with polyarticular JIA, 32 of them received etanercept and 22 received abatacept. The demographic parameters were well matched across treatment groups. The mean age of children was 10.8 ± 3.7, the age at the disease onset was 5.4 ± 3.4, most of the patients were female. Prior to biological DMARD administration, all the subjects received multiple ...

BACKGROUND: Etanercept is a fully human tumor necrosis factor a receptor fusion protein that binds tumor necrosis factor a with greater affinity than natural receptors. Biologics are widely used in the treatment of psoriasis and psoriasis arthritis and may represent a new therapeutic option for some patients with psoriatic nail disease. CASE REPORT: We report a case of lichen planus limited to ...

Diet-induced obesity (DIO) is considered the main risk factor for cardiovascular diseases. Increases in plasma levels of tumor necrosis alpha (TNF-α) associated with DIO. Etanercept, a TNF-α inhibitor, has been shown to alleviate cardiac hypertrophy. To investigate effect etanercept on fibrosis DIO model, rats high fat diet (HFD) were subdivided into two groups: group and vehicle group. Cardiac...

Background In the UK etanercept is licensed for use in children with JIA age 4–17 years with active polyarticular disease which has not fully responded to or the child has been intolerant to methotrexate [1]. Studies have shown that the annual cost of treatment with the addition of etanercept is only slightly higher than prior costs because of reduced inpatient and outpatient visits, reduction ...

Objective. To evaluate the effects of etanercept treatment on patient-reported outcomes (PRO) in patients with psoriatic arthritis (PsA). Methods. A 24-week double-blind comparison to placebo was followed by a 48-week open-label phase in which all eligible patients received etanercept. PRO were measured using the Stanford Health Assessment Questionnaire Disability Index (HAQ-DI), the Medical Ou...