recurrence of pulmonary tuberculosis and was started on the same four medications at a local clinic. One day after the initiation of this treatment, he noted jaundice, abdominal pain and oliguria. Admission laboratory data were as follows: blood urea nitrogen, 71.6mg/dl (25.5mmol/l); creatinine, 5.2mg/dl (459mmol/l); albumin, 4.0 g/dl (40 g/l); total bilirubin, 14.0mg/dl (238mmol/l); direct bil...

To compare the sensitivity of 2 microscopic methods for diagnosis Mycobacterium tuberculosis (M.tb) along with culture and drug susceptibility testing to first line drugs. : The cross-sectional study comprises 200 suspected cases pulmonary both clinically radiologically in KIMS, Bangalore over a period years. Samples (sputum/BAL fluid) were collected, processed stained by Ziehl Neelson (ZN) Flu...

BACKGROUND Current guidelines for dosing of anti-TB drugs in children advocate higher doses for rifampicin and isoniazid despite limited availability of paediatric data on the pharmacokinetics of these drugs, especially from Africa, where the burden of childhood disease remains high. METHODS Thirty children aged 6 months to 15 years underwent intensive pharmacokinetic sampling for first-line ...

Exposure to lower-than-therapeutic levels of anti-tuberculosis drugs is likely to cause selection of resistant strains of Mycobacterium tuberculosis and treatment failure. The first-line anti-tuberculosis (TB) regimen consists of rifampicin, isoniazid, pyrazinamide, and ethambutol, and correct management reduces risk of TB relapse and development of drug resistance. In this study we aimed to in...

Preliminary studies showed that roxithromycin possessed significant in vitro activity against a variety of atypical mycobacteria such as the Mycobacterium avium complex, M. scrofulaceum, M. szulgai, M. malmoense, M. xenopi, M. marinum, and M. kansasii and rare pathogens such as M. chelonae and M. fortuitum. In this investigation, radiometric MICs of roxithromycin, ethambutol, rifampin, amikacin...

INTRODUCTION The aim of this study was to analyse the thickness of the retinal nerve fibre layer (RNFL) of pulmonary tuberculosis patients on ethambutol and isoniazid. MATERIALS AND METHODS This was a prospective cohort study where patients with newly diagnosed pulmonary tuberculosis requiring chemotherapy, including ethambutol and isoniazid, were imaged using scanning laser polarimetry. Thei...

Tuberculosis (TB), caused by strains of Mycobacterium tuberculosis complex (M. tuberculosis), is a pulmonary infection that is spread by airborne droplet transmission. The development and spread of drug-resistant strains of M. tuberculosisgreatly jeopardize TB control efforts. We report the case of a previously healthy 43-year-old male, visiting from China, who presented to the emergency depart...

The present study was conducted to find out the ethambutol resistance pattern of indigenous isolates of Mycobacterium tuberculosis from Tuberculosis diagnosed human patients. A total of 172 specimens were collected from six different sources and comprised of 84.9% sputum, 10.5% pus and 4.7% bronchial washings. There were 70.9% males and 29.1% females with 84.30% pulmonary and 15.69% extra-pulmo...

This study was conducted to evaluate the visual field changes in tubercular patients on anti-tubercular therapy and assess reversibility of these after discontinuation therapy. as a prospective analytical at tertiary care centres Bhopal Jabalpur all newly detected tuberculosis patients. Ocular history, relevant history recorded detailed ocular examination done time presentation, before initiati...