Fatty acids may promote type 2 diabetes by altering insulin secretion from pancreatic cells, a process known as lipotoxicity. The underlying mechanisms are poorly understood. To test the hypothesis that peroxisome proliferator-activated receptor (PPAR ) has a direct effect on islet function, we treated INS-1 cells, an insulinoma cell line, with a PPAR adenovirus (AdPPAR ) as well as the PPAR ag...
