Abstract: Background: The objective of this current study was to fabricate and characterize the sustained release double layered transdermal patches Diclofenac Diethylamine using hydrophobic acrylic polymer Eudragit RL 100 hydrophilic Polyvinyl pyrrolidone K-30 in combination as first layer matrix type patch pressure sensitive adhesive Duro Tak 387- 2510 second drug-in-adhesive provide anti-inf...

Metformin hydrochloride is recommended globally as first line therapy due to its favorable profile on morbidity and mortality associated with type-2 diabetes mellitus. However, limitations of multiple dosing and risk of triggering gastrointestinal symptoms make its dose optimization difficult. Extended-release metformin matrix tablets were prepared by direct compression of drug and different pH...

An ideal drug delivery system will possess three main properties: (a) It will be a single dose for the whole duration of treatment. (b) It will deliver the active drug directly at the site of action. (c) It will possess possible fewer side effects. Above approaches are achieved with the help of suitable choice of polymer. When it comes to targeted drug release profiles, Eudragit is the pharmace...

The objective of this study was to develop a novel bacterially-triggered micro-particular system of de-esterified tragacanth (DET) in combination with Eudragit S-100 coated capsules for colon drug delivery of 5-fluorouracil (5-FU) using microemulsion method. The loading study was conducted at different drug-to-polymer ratios and cross-linker concentrations. The maximum loading efficiency was ac...