Derived-band click-evoked auditory brainstem responses (ABRs) were obtained for normal-hearing (NH) and sensorineurally hearing-impaired (HI) listeners. The latencies extracted from these responses, as a function of derived-band center frequency and click level, served as objective estimates of cochlear response times. For the same listeners, auditory-filter bandwidths at 2 kHz were estimated u...

UNLABELLED The purpose of this study was to determine whether session-specific measures of negative pain-related affect would account for longitudinal variability in the ratings of the evoked thermal pain. Pain-free subjects rated pain evoked on the posterior leg using thermal stimuli of 45 degrees , 47 degrees , 49 degrees , and 51 degrees C on 3 occasions, each separated by 2 weeks. Session-s...

Selective excitation of the human visual cortex by patterned stimuli was examined in a randomly selected sample of normal adtdts and adults with severe monocular visual loss resulting from childhood strabismic amblyopia. Six of the eight normal eyes showed selective but variable configuration cortical evoked responses (VER, passband 0.2 to 50 Hz.) to patterned stimulation when lenses were used ...

The rodent primary somatosensory cortex is spontaneously active in the form of locally synchronous membrane depolarizations (UP states) separated by quiescent hyperpolarized periods (DOWN states) both under anesthesia and during quiet wakefulness. In vivo whole-cell recordings and tetrode unit recordings were combined with voltage-sensitive dye imaging to analyze the relationship of the activit...

There has been an explosion of research using transcranial direct current stimulation (tDCS) for investigating and modulating human cognitive and motor function in healthy populations. It has also been used in many studies seeking to improve deficits in disease populations. With the slew of studies reporting "promising results" for everything from motor recovery after stroke to boosting memory ...

Anderson et al. (Variability not ability: another basis for performance decrements in neglect. Neuropsychologia 2000;38:785-796) have recently reported that variability of response times (RTs) progressively increases from the right to the left side in left neglect patients. Anderson et al. propose that this lack of consistency is an important determinant of patients' behaviour, and may result f...

Neocortical neurons show astonishing variation in the presence and timing of action potentials across stimulus trials, a phenomenon whose function and significance has been the subject of great interest. Here we present data showing that this response variability can be significantly reduced by altered sensory experience. Removal of all but one whisker from the side of the mouse face results in...