Azithromycin (AZ) is an azalide macrolide antibiotic that frequently employed for treating bacterial skin infections. It suffers from limited oral bioavailability, which results incomplete absorption or extensive first-pass metabolism. Therefore, preparing azithromycin formulations topical administration highly recommended to avoid metabolism and boost the concentration of drug on skin. The obj...

Abstract: Introduction: The purpose of the present study was to design, develop, and characterize transdermal patches containing Simvastatin for management blood lipid levels. Materials Methods: Transdermal were prepared by solvent casting method. evaluated physicochemical characteristics such as thickness, weight variation, folding endurance, percentage moisture uptake, content, drug ex-vivo p...

Abstract: Background: Acyclovir is a potent antiviral agent primarily used to treat viral infection in the eye, signified as Herpes Simplex Keratitis caused by Virus-1. But its applications are limited because of poor oral bioavailability and permeability significant first-pass metabolism. Objectives: The study design formulation, optimization, in-vitro, ex-vivo in-vivo characterization solid l...

     The purpose of the present study was to explore the passive and electrically assisted transdermal transport of Granisetron hydrochloride (GRA) in solution and gel formulation through iontophoresis and also the feasibility of delivering therapeutic amounts of drug for the treatment of chemotherapy-induced nausea and vomiting. In this study, iontophoretic permeation of GRA through guinea pig...

Thermoreversible biogels can serve as effective systems for delivery of drugs through nose with increased nasal residence time. The objective of this study was to use chitosan and glycerophosphate based thermoreversible systems for delivery of doxepin to brain through intranasal administration. Formulations were prepared by admixture of suitable dilutions of chitosan and glycerophosphate with o...

Objective: The application of human cord blood (hCB) is limited to children by using relatively small volume of cord blood that does not contain enough hematopoietic stem cells (HSCs). So, efforts for applying cord blood stem cells in transplantation have led to establishment of some approaches for ex vivo expansion of HSCs such as garcinol. Materials and Methods: CD133+ HSCs were separated by ...

Nitroglycerin (NTG) is an organic nitrate rapidly denitrated by enzymes to release free radical nitric oxide and shows improved wound healing and tissue protection from oxidative damage. The purpose of this study was to evaluate whether topical application of NTG in the form of gel/ointment along with a natural wound healing agent, aloe vera, would bring about wound healing by using diabetes-in...

Poly(D,L-lactide-co-glycolide) and poly(D,L-lactide-co-glycolide) with poly(ethylene glycol) nanospheres (NSs) incorporating flurbiprofen (FB) were freeze-dried with several cryoprotective agents and sterilized by γ-irradiation. Only when 5.0% (w/v) hydroxypropyl-β-cyclodextrin (HPβCD) was used, a complete resuspension by manual shaking and almost identical particle size of the NSs was obtained...

OBJECTIVES To morphologically evaluate the permeability of different commercial dental adhesives using scanning electron microscopy. METHODS SEVEN ADHESIVE SYSTEMS WERE EVALUATED: one three-step system (Scotchbond Multi-Purpose - MP); one two-step self-etching primer system (Clearfil SE Bond - SE); three two-step etch-and-rinse systems (Single Bond 2 - SB; Excite - EX; One-Step - OS); and two...