Vitiligo is a common autoimmune disease of the skin that results in disfiguring white spots. There are no Food and Drug Administration (FDA)-approved treatments, and current treatments are time-consuming, expensive, and of low efficacy. We sought to identify new treatments for vitiligo, and first considered repurposed medications because of the availability of safety data and expedited regulato...

Autoimmune disturbances and metabolic abnormalities observed in vitiligo, a disease of still unclear etiology, may provide evidence on the systemic nature of the disease. The aim of the study was to assess functional and morphological parameters of the liver and spleen, as well as the lipid profile in vitiligo-affected children, in order to ascertain whether any metabolic abnormalities or struc...

Calreticulin (CRT), a damage-associated molecular pattern (DAMP) molecule involved in immune response, is reported to translocate from endoplasmic reticulum cell membrane melanocytes under oxidative stress. The present study aimed investigate the mechanism underlying stress-induced membranal translocation of CRT as well potential role pathogenesis vitiligo, which skin disease featured by autoim...

Vitiligo is an autoimmune disease characterized by depigmentation of the skin due to destruction of melanocytes. Interferons have been used for the treatment of chronic hepatitis C and some malignancies. We report interferon alpha-2a-induced vitiligo in a male patient with chronic active hepatitis C. All skin lesions disappeared completely without requiring therapy after discontinuation of inte...

results this cross-sectional study included 92 patients (47 male and 45 female) with mean age of 32.1 ± 13.16 years (ranging from nine to 61 years of age). mean duration of vitiligo was 10.84 ± 10.17 years. the most common distribution of the lesions was on the upper limbs (60.8%) and the least was on the genital region (10.8%). positive family history was found in 26 (28.3%) patients. diabetes...

vitiligo Generalized vitiligo (GV) is the most common depigmentation disorder, in which acquired multifocal patches of white skin and overlying hair result from loss of melanocytes in the involved areas (Figure 1) [1,2]. Th e prevalence of GV is approximately 0.5% in various populations [3], with an average age of onset at about 24 years and occurring with approximately equal frequency in males...

Vitiligo is an autoimmune skin disorder characterized by acquired white patches of skin and overlying hair as a consequence of loss of melanocytes and cutaneous pigment from the involved areas [1]. It appears mainly in patients with autoimmune disorders, although it has also been rarely described in patients with inflammatory bowel disease either before or after the establishment of diagnosis o...

<p class="abstract"><strong>Background: </strong>Vitiligo is characterized by milky-white macules affecting the skin and mucous membranes. It occurs due to progressive loss of functioning melanocytes from affected areas. may affect any age group gender. Genetic, immunological, neural, self-destructive mechanisms be involved in its pathogenesis. Both autoimmune non-autoimmune d...

Melanocyte loss in vitiligo vulgaris is believed to be an autoimmune process. Macrophage migration inhibitory factor (MIF) is involved in many autoimmune skin diseases. We determined the possible role of MIF in the pathogenesis of vitiligo vulgaris, and describe the relationship between MIF expressions and disease severity and activity. Serum MIF concentrations and mRNA levels in PBMCs were mea...

Vitiligo, an autoimmune disorder, is known to co-localize with other immunological disorders like lichen planus and psoriasis. However, there are no reports regarding the co-localization of an autoimmune disorder (vitiligo) and a developmental disorder (verrucous epidermal nevus). We hereby present a 10-month-old infant who was visited for white patches on the right buttock and adjoining antero...