Finding optimal operating conditions fast for process systems is a key competitive factor in fine chemicals and pharmaceutical industrial sectors to increase the value added in many stages of a product/process lifecycle. To deal successfully with noise and bias in experimental optimization a statistical characterization of a local optimum that is more amenable for process outputs rather than nu...

Because of complex interactions among the components of PCR and the wide and increasing variety of applications in which this technique is used, optimization is necessary for every reaction. Here we describe the use of experimental design techniques (2k fractional factorial design and central composite design) to attain easier, quicker and cheaper PCR optimization of DNA from blood spots. By de...

In this article, we propose an efficient approach to find optimal experimental designs for event-related functional magnetic resonance imaging (ER-fMRI). We consider multiple objectives, including estimating the hemodynamic response function (HRF), detecting activation, circumventing psychological confounds and fulfilling customized requirements. Taking into account these goals, we formulate a ...

in the last quarter of the century, a substantial amount of research work has been conducted on optimization of energy consumption by refrigeration systems and on proper design and construction of household refrigerator-freezers. the importance of such energy optimization schemes stems from the environmental impacts of freon (r-12) used as the working refrigerant in household refrigerator – fre...

A fully experimental modeling technique and a design optimization procedure are presented in this paper for push-pull electret loudspeakers. Conventional electrical impedance-based parameter identification methods are not completely applicable to electret speakers due to the extremely weak electromechanical coupling. This prompts the development of an experimental technique for identifying the ...

This paper describes an approach to harvest electrical energy from a mechanically excited piezoelectric element. The structure of piezoelectric energy harvester is optimized for maximum power with minimum dimensions through Genetic Algorithm approach to enhance the conversion of mechanical energy into electrical energy using direct piezoelectric effect. Numerical analysis is carried out to obta...

During the last decades a number of studies on modifications and improvement of the original algorithm have been published. The first design matrix is however one aspect of simplex optimization that has raised substantially less interest, despite the observation of its importance for the speed of convergence by Nelder and Mead. This is probably due to the fact that Spendley et al already in the...

SELF LEARNING STRATEGIES FOR EXPERIMENTAL DESIGN ANDRESPONSE SURFACE OPTIMIZATIONby

Fenofibrate lipospheres were prepared by the melt dispersion technique. Critical parameters influencing particle size and entrapment efficiency were optimized by applying the L9 Taguchi experimental design. Entrapment efficiency of up to 87 % was obtained for the optimized formulation on increasing olive oil up to 30 % in the lipid carrier. Particle size analysis by microscopy and SEM revealed ...