Autosomal dominant hypocalcemia (ADH), caused by activating mutations of the calcium-sensing receptor (CaSR), is characterized by hypocalcemia with an inappropriately low concentration of PTH. Among 11 missense mutations of CaSR reported to date in patients with ADH or sporadic hypocalcemia, functional properties of 8 mutant CaSRs were characterized. Here, we describe a novel mutation of CaSR a...

BACKGROUND Postoperative hypocalcemia is one of the most common complications of thyroid surgery. It is related to the type of disease (malignant or benign), the number of identified parathyroid glands during the surgical procedure, and the surgeon's experience. Total thyroidectomy is the procedure of choice in our hospital for benign and malignant thyroid disease, but it can increase the incid...

Monitoring renal function and adjusting dosing for patients with impaired renal function are not required with denosumab (60 mg every 6 months). However, these patients have an increased risk for developing hypocalcemia. This case report describes a patient with renal impairment who developed severe hypocalcemia after receiving denosumab.

Hypocalcemia is one of the common complications after total thyroidectomy. In these patients, serum parathyroid hormone (PTH), calcium level decreases, and phosphorus increases. The fibroblast growth factor-23 (FGF-23), a phosphaturic hormone, increases in to normalize level. our study, we aimed investigate predictive values PTH, calcium, phosphorus, 1,25-dihydroxy vitamin D (vitamin D), FGF-23...

BACKGROUND Development of hypocalcemia after treatment of hyperparathyroidism results in increased costs and risk of poorer outcomes. Previous studies have shown conflicting data about predictors of hypocalcemia after these procedures. HYPOTHESIS/OBJECTIVES The objective of this study was to investigate whether ionized calcium (iCa) concentrations before treatment are predictive of hypocalcem...

Results Transient, mild but significant decrease of serum calcium levels was observed after surgery in up to a fifth of patients, while severe hypocalcemia was shown in about 5% of patients. The reduction of calcemia was more evident in elderly patients, with a concomitant reduction of albuminemia. In severe hypocalcemia, in addition to these two findings, decrease of parathormone levels was sh...

The trousseau’s sign is carpopedal spasm that results from ischemia that is induced by pressure applied to the upper arm. It is a sensitive and specific sign of hypocalcemia. Here the author is sending the short case summary, images of the demonstration of the Trousseau’s sign. This case also had a cluster of seizures induced by hypocalcemia.

Introduction: This study aimed to investigate whether pre-operative dexamethasone could ameliorate transient hypoparathyroidism outcome through total thyroidectomy.   Materials and Methods: This randomized clinical trial study was conducted on 128 patients underwent total thyroidectomy from March 2014 to April 2015. Patients were randomly assigned to two groups of experimental receiving 8 mg IV...

AIM Definitive hypoparathyrodism (hypo-PTH) represents one of the most dangerous complication after total thyroidectomy. Partial or total lesion or accidental removal of parathyroid glands is an unpredictable adverse event, although real incidence is not well defined, such as management of this deficit. We started a prospective evaluation of patients treated with total thyroidectomy in our cent...

Hypocalcemia is a known cause of reversible cardiomyopathy and DiGeorge syndrome is an important cause of hypocalcemia. A 17 days old 2.3 kg female child, first in birth order, born to a primigravida mother by full term LSCS started having tonic-clonic jerks on day 8 of life and was also noticed to have bluishness of lips and nails, when she was referred to us. Child had intermittent episodes o...