Using statistical methods to assess human exposure to environmental pollutants is a relatively new concept in environmental sciences. This paper contains discussion of (1) the importance of exposure studies to EP A's environment research and regulatory efforts; (2) new approaches to measuring total human exposure; (3) several recent human exposure field studies, looking at the specific contribu...

To avoid motion artefacts when merging multiple exposures into a high dynamic range image, a number of HDR deghosting algorithms have been proposed. However, these algorithms do not work equally well on all types of scenes, and some may even introduce additional artefacts. As the number of proposed deghosting methods is increasing rapidly, there is an immediate need to evaluate them and compare...

On the basis of 32P-postlabeling analysis, treatment of rats with 1-nitropyrene (1-NP) resulted in the formation of multiple DNA adducts in the liver, mammary glands, and peripheral lymphocytes. The one adduct resulting from nitroreduction, N-(deoxyguanosin-8-yl)-1-aminopyrene, constitutes only a minor component among the adducts. In the present study, incubation of calf thymus DNA with mutagen...

Sulfur mustard (SM, 2, 2'-dichlorodiethyl sulfide) is an alkylating vesicating agent. The injuries resulting from SM exposure are mainly characterized by epithelial damage of the tissues through which it is absorbed, i.e., skin, eye, and respiratory tract. The skin blistering action of SM is not seen until about 12–24 hr after exposure. This time lag provides a window of opportunity for an earl...

The Environmental Public Health Tracking Network (EPHTN) proposes to link environmental hazards and exposures to health outcomes. Statistical methods used in case-control and cohort studies to link health outcomes to individual exposure estimates are well developed. However, reliable exposure estimates for many contaminants are not available at the individual level. In these cases, exposure/haz...

Currently, about 75% of Finnish reinforced polyester lamination workers are exposed to styrene concentrations exceeding the current occupational exposure limit of 20 ppm. Several measures have been proposed to control styrene exposure, but only a few of them are capable of keeping the styrene concentration below 20 ppm. The present study was carried out to evaluate current ventilation systems i...

This work presents an attempt to develop a group contribution based model for toxicological quantities. For example, LC50, LD50 and acute exposure guideline levels (AEGL). The first two quantities are modelled based on linear estimation of group contributions using measured data from the literature. Group contributions are also developed for, i. AEGL data published by the U.S. National Research...

background: mercury is widespread and persistent in the environment. one organic form of mercury, methylmercury (mehg), can accumulate in the food chain in aquatic ecosystems and lead to high concentrations of mehg in fish, which, when consumed by humans, can result in an increased risk of adverse effects. currently, the joint fao/who expert committee on food additives (jecfa) has established p...

purpose: to evaluate exposure rate following wrapping hydroxyapatite implant in mersilene mesh and donor sclera. methods: in a prospective comparative interventional case-series 60 consecutive patients underwent primary hydroxyapatite orbital implant wrapped in mersilene mesh or donor sclera. results: thirty patients (21 male and 10 female) underwent implantation with mersilene mesh and 30 pati...

Potential reduced exposure products (PREPs) to tobacco toxicants may have promise in reducing tobacco-related morbidity or mortality or may promote greater harm to individuals or the population. Critical to determining the risks or benefits from these products are valid human clinical trial PREP assessment methods. Such an assessment involves determining the effects of these products on biomark...