conclusions evaluation of iranian traditional dosage forms like vaginal and rectal types could be an attractive topic of research and the current study can briefly represent the iranian traditional pharmaceutical knowledge on vaginal and rectal drug delivery. objectives the aim of this study is the investigation about iranian traditional pharmaceutical dosage forms of vaginal and rectal medicat...

Bupropion hydrochloride (HCI) is an antidepressant that acts as a norepinephrine and dopamine reuptake inhibitor and has three different dosage forms including immediate release (IR), sustained release (SR), and extended release (ER). Despite its relatively safe side effect profile bupropion may cause several side effects. Here, we aimed to report a case with major depression using extended rel...

NEW DRUG APPROVALS Adzenys XR-ODT for ADHD The FDA has given the green light to Adzenys XR-ODT (Neos Therapeutics) for the treatment of attention -deficit/ hyperactivity disorder (ADHD) in patients 6 years of age and older. With this approval, the product is the first extended-release orally disintegrating tablet (ODT) for this indication. Adzenys XR-ODT contains amphetamine loaded onto a mixtu...

BACKGROUND There has been a long-standing debate regarding whether aminoglycosides should be administered on a multiple daily dosing (MDD) or once-daily dosing (ODD) schedule. Several unique characteristics of the aminoglycosides make ODD an attractive and possibly superior alternative to MDD. These include concentration-dependent bactericidal activity; postantibiotic effect, which allows conti...

INTRODUCTION The Basic Surgical Skills course uses an assessment score interval of 0-3. An extended score interval, 1-6, was proposed by the Swedish steering committee of the course. The aim of this study was to analyze the trainee scores in the current 0-3 scored version compared to a proposed 1-6 scored version. METHODS Sixteen participants, seven females and nine males, were evaluated in t...

The exact computation of orbits of discrete dynamical systems on the interval is considered. Therefore, a multiple-precision floating point approach based on error analysis is chosen and a general algorithm is presented. The correctness of the algorithm is shown and the computational complexity is analyzed. As a main result, the computational complexity measure considered here is related to the...

Many ambitious computer algebra systems were initially designed in a flush of enthusiasm, with the goal of automating any symbolic mathematical manipulation “correctly.” Historically, this approach resulted in programs that implicitly used certain identities to simplify expressions. These identities, which very likely seemed universally true to the programmers in the heat of writing the CAS, (a...

This paper describes an implementation of a general interval arithmetic extension, which comprises the following extensions of the conventional interval arithmetic: (1) extension of the set of normal intervals by improper intervals; (2) extension of the set of arithmetic operations for normal intervals by nonstandard operations; (3) extension by infinite intervals. We give a possible realizatio...

Many ambitious computer algebra systems were initially designed in a flush of enthusiasm, with the goal of automating any symbolic mathematical manipulation “correctly.” We see this kind of goal in programs like Macsyma, Maple, Mathematica. This approach often resulted in programs that implicitly used certain identities to simplify expressions. These identities, which likely seemed universally ...

BACKGROUND Aminoglycosides are mandatory in the treatment of severe infections in burns. However, their pharmacokinetics are difficult to predict in critically ill patients. Our objective was to describe the pharmacokinetic parameters of high doses of tobramycin administered at extended intervals in severely burned patients. METHODS We prospectively enrolled 23 burned patients receiving tobra...