We conducted this study to assess the efficacy of intermittent short course therapy in all forms of pediatric tuberculosis using a coordinated approach with Revised National Tuberculosis Control Programme (RNTCP). Sixty five children were treated using RNTCP protocols with some modifications, such as dose adjustments or prolongation of treatment in selected children. Overall response rate was 9...

Introduction: Increased occurrence of tuberculosis in diabetic population is known since long time. Tuberculosis (TB) remains one the world’s deadliest communicable diseases and India currently bears highest burden World. Diabetes mellitus (DM) becoming epidemic 21st century with having second largest populationglobally. This emphasizes importance investigating association diabetes mellitus.Aim...

INTRODUCTION Expression of Suppressor of cytokine signaling (SOCS)-1 molecules is increased in patients with tuberculosis (TB). Early Secreted Antigen Target (ESAT)-6 kDa - induced IFN-γ responses indicate Mycobacterium tuberculosis infection. The effect of ESAT6- stimulation on SOCS1 in the host is not known. METHODOLOGY Healthy asymptomatic controls had a negative (n = 16) or a positive ( n...

a 46- year–old man with pulmonary tuberculosis which had treated with ant tuberculosis drugs was referred to medical mycology laboratory, school of public health and institute of public health research for coughing and bloody sputum. chest x-ray revealed a cavern with a moveable mass in right apical lobe. direct examination of sputum showed wide septated dichotomous hyphae and aspergillus fumig...

background human immunodeficiency virus (hiv) testing strategy for tuberculosis (tb) patients in some high hiv incidence countries has been recommended based on interaction between hiv and tb. objectives the present study aimed to determine the prevalence of hiv infection among newly detected pulmonary tb patients. patients and methods in a cross sectional study,104 cases including 95 non injec...

BACKGROUND Quick diagnosis of smear-negative pulmonary tuberculosis (TB) and extra-pulmonary TB are urgently needed in clinical diagnosis. Our research aims to investigate the usefulness of the interferon-γ release assay (IGRA) for the diagnosis of smear-negative pulmonary and extra-pulmonary TB. METHODS We performed TB antibody and TB-IGRA tests on 389 pulmonary TB patients (including 120 sm...

Objectives: This study was undertaken to see the role of AFB microscopy and culture for the diagnosis of extra pulmonary tuberculosis. Design and Setting: This descriptive study was carried out at PMRC TB Research Centre King Edward Medical University/Mayo Hospital Lahore. Subject and Methods: Symptomatic suspects of extra-pulmonary TB were asked to submit their respective samples for AFB smear...

background : multi drug-resistant mycobacterium tuberculosis (mdr-tb) is an infection with a causative bacillus which is resistant to at least two drugs, isoniazid and rifampin. the purpose of this study is to evaluate the prevalence of tb resistance to first-line drugs of newly diagnosed active pulmonary tuberculosis. methods : this cross-sectional study was performed on 77 patients with newly...

conclusions concurrent pulmonary nocardiosis and tuberculosis is frequent in hiv-infected patients. rapid and sensitive methods such as pcr are recommended for detection of such co-infections. results from 157 sputum specimens, positive samples by acid fast staining, culture and pcr for m. tuberculosis were reported for 7.6% (12/157), 10.1% (16/157) and 7% (11/157) of samples, respectively. no ...