actinomycetes are an uncommon agent of human infections and its pathogenic factors are not known. the present study reports a rare case isolation of an actinomycete from a woman pleural fluid; the strain was identified by 16s rrna gene sequence analysis. this strain was tested to produce an extracellular protease that hydrolysis gelatin, casein and hemoglobin on agar mediums. the purification o...

Cover Illustration: Electron micrograph showing an area near the interaction sites between Iba1-immunostained microglial cell (shaded in violet) and surface of a motor neuron at spinal cord ventral horn red) following sciatic nerve transection. The extracellular space is delimited yellow. Extracellular multilamellar bodies vesicles derived from degenerating afferent synaptic boutons are seen in...

Extracellular vesicles (EVs) secreted by cancer cells play a key role in the microenvironment and progression.

urokinase plasminogen activator receptor (upar) and its ligands play a major role in many tumors by mediating extracellular matrix degradation and signaling cascades leading to tumor growth, invasion and metastasis. recently we introduced upar decapeptide antagonist with cytotoxic effect on mda-mb-231 cell line. in this study we assessed the alteration in upar downstream signaling following tre...

Objective(s): Valproic and arundic acids are astrocytes-modulating agents with potential effects in the treatment of Alzheimer’s disease (AD). S100B is an astrocytic cytokine with a possible role in the pathogenesis of AD. In this study, we aimed to assess the glioprotective effects of valproic and arundic acids against amyloid-β-peptide (Aβ)-induced glial death and co...

Background: Parthenogenetic activation is a possible way to produce homogeneous embryos with the some ploidy. Probably such embryos could be used in other areas of biotechnology. Calcium signals are known as important regulators of oocyte activation. Extracellular calcium is required for initiation of meiotic resumption and development. Calcium ionophore A23187 is known to elevate intracellular...

Infertility as a vital process in human reproduction involves many couples worldwide. Although many genetic causes of infertility are known, the genetic basis of infertility in men is largely unknown. Therefore, the identification of genetic biomarkers in this field is important and genetic polymorphisms in key genes of the spermatogenesis pathway can be valuable biomarkers in this field. Gene'...

Many studies reported that redox enzymes, particularly thioredoxin and peroxiredoxin, can be released by cells act as soluble mediators in immunity. Recently, it became clear peroxiredoxins secreted via the exosome-release route, yet remains unclear how this exactly happens why. This review will first introduce briefly possible states of protein cysteines role enzymes their regulation. We then ...

Green extracellular synthesis of the Fe2O3 nanoparticles by a native marine bacterium, Alcaligenes sp. strain NV06