The interaction between neuroleptics and an anticholinergic, biperiden, in the antiavoidance, catalepsy and ptosis tests was investigated in mice for the purpose of predicting the extrapyramidal side-effects of neuroleptics. The cataleptic effect of most neuroleptics used was antagonized to some extent by biperiden, while the ptotic effect was hardly influenced. The antiavoidance effect of halo...

Sporadic Creutzfeldt-Jakob disease (CJD) is clinically characterized by rapidly progressive dementia combined with other cardinal symptoms, such as myoclonus, visual or cerebellar disturbances, extrapyramidal or pyramidal disturbance, and akinetic mutism. However, as an initial manifestation, focal neurologic deficits other than the aforementioned or nonspecific generalized symptoms may lead to...

Results Therewere significant differencesbetweenthe premorbid groups on change onthe Positive and Negative Syndrome Scale,Clinical Global Impression severity and cognitive functioningand Extrapyramidal Symptoms Rating Scale.Patients inthe ‘stable^good’premorbid group (n1⁄4251) improvedmore thanthose in the‘stable^ poor’ (n1⁄4198) and‘declining’ (n1⁄481) groups.The‘stable^good’group received the...

selective estrogen receptor modulators (serms) such as raloxifene have already shown beneficial effects on negative, positive and general psychopathology symptoms in postmenopausal women with schizophrenia. the purpose of the present investigation was to assess the efficacy of raloxifene as an adjuvant agent in the treatment of men with chronic schizophrenia in an 8-week double-blind and placeb...

BACKGROUND We present the case of a 52-year-old woman with depression who developed extrapyramidal symptoms (mainly parkinsonism) and suicidal ideation while on fluoxetine. METHODS The patient underwent neurological and neuroimaging examination. RESULTS The patient's neurological and neuroimaging examinations were normal and there was no other cause of extrapyramidal symptoms. The patient s...

Background Molybdenum cofactor deficiency (MoCD) (OMIM # 252150) is an autosomal-recessive disorder caused by mutations in four genes involved the molybdenum (MOCO) biosynthesis pathway. Objectives We report a milder phenotype patient with MOCS1 gene mutation who presented Leigh-like presentation. Case present case of 10-year-old boy was symptomatic at age 5 months sudden onset dyskinesia, nyst...

A 15-year old girl with slowly progressive gait and speech disorders, and with impairment of mental ability, is decsribed. The disease appeared 18 months before the first hospitalization at the Department of Neurology and Physchiatry for Children and Young People. Neurological and other examinations confirmed extrapyramidal and cerebellar signs, conspisuous knee and ankle reflexes, marked splen...

“Hallervorden-Spatz disease” represents a distinctive and readily recognizable eponym to neurologists and pediatricians; it denotes a rare, inherited, autosomal recessive disorder tha t is perhaps a neuraxonal dystrophy, characterized by the childhood onset of unrelenting progressive gait disturbance, spasticity, and dementia associated with prominent extrapyramidal signs such as dystonia, chor...