Superficial cutaneous burns following lightning strike may vary in patterns ranging from linear burns, punctate burns, feathering burns, and thermal burns. Contact with an extrinsic object in the pathway of lightning current can lead to disastrous consequences. The lucky who survive may show bizarre and interesting burn patterns to tell their story.

The signaling adaptor p62 is a multidomain protein implicated in the activation of the transcription factor NF-kappaB. Recent findings link p62 activity to the extrinsic apoptosis pathway, and Mathew et al. (2009) now show that the modulation of p62 by autophagy is a key factor in tumorigenesis. These findings place p62 at critical decision points that control cell death and survival.

BACKGROUND HIV infection leads to activation of coagulation, which may increase the risk for atherosclerosis and venous thromboembolic disease. We hypothesized that HIV replication increases coagulation potentially through alterations in extrinsic pathway factors. METHODS AND RESULTS Extrinsic pathway factors were measured among a subset of HIV participants from the Strategies for Management ...

Several studies have suggested that the partially fermentable fibre Plantago ovata husk (PO) may have a protective effect on colorectal cancer (CRC). We studied the potentially pro-apoptotic effect of PO and the implicated mechanisms in CRC cells with different molecular phenotypes (Caco-2, HCT116, LoVo, HT-29, SW480) after PO anaerobic fermentation with colonic bacteria as it occurs in the hum...

Polychlorinated biphenyls (PCBs) can disrupt the endocrine function, promote neoplasms and regulate apoptosis in some tissues; however, it is unknown whether PCBs can affect the apoptosis of pituitary cells. The study evaluated the effect of PCBs on the apoptosis of normal pituitary cells and the underlying mechanisms. Primary cell cultures obtained from mouse pituitary glands were exposed to A...

BACKGROUND This study was designed to determine whether arterial reocclusion after thrombolysis can be prevented by lipoprotein-associated coagulation inhibitor (LACI), a physiological inhibitor of tissue factor-induced coagulation mediated by the extrinsic pathway. METHODS AND RESULTS Thrombosis was induced in femoral arteries of anesthetized dogs with the use of anodal current to elicit ext...

ABSTRACT The balance between stem cell potency and lineage specification entails the integration of both extrinsic intrinsic cues, which ultimately influence gene expression through activity transcription factors. One example this is provided by Hippo signalling pathway, plays a central role in regulating organ size during development. pathway mediated transcriptional co-factors Yes-associated ...

Abstract The maintenance of hemostasis to ensure vascular integrity is dependent upon the rapid conversion zymogen species coagulation cascade their enzymatically active forms. This process culminates in generation serine protease thrombin and polymerization fibrin prevent leak at sites endothelial cell injury or loss cellular junctions. Thrombin can be initiated by extrinsic pathway through ex...

‎Based on a definition for circle in Finsler space‎, ‎recently proposed by one of the present authors and Z‎. ‎Shen‎, ‎a natural definition of extrinsic sphere in Finsler geometry is given and it is shown that a connected submanifold of a Finsler manifold is totally umbilical and has non-zero parallel mean curvature vector field‎, ‎if and only if its circles coincide with circles of the ambient...

Oxaliplatin-based chemotherapy improves the outcomes of metastatic colorectal cancer patients. Its most significant and dose-limiting side effect is the development of a neuropathic syndrome. The mechanism of the neurotoxicity is unclear. The limited knowledge about differences existing between neurotoxic and antitumor effects hinders the discovery of effective and safe adjuvant therapies. In v...