PURPOSE To develop a new animal model of anterior subcapsular cataract formation by topical application of alkali to the eye and to examine the role of Transforming growth factorbeta/Smad3 (TGFbeta/Smad3) signaling in the formation of this cataract model. METHODS Under anesthesia, one eye of adult Wistar rats (n=142) was subjected to alkali burn by topical application of 1 N NaOH. The eye was...

PURPOSE To compare central corneal swelling and light scatter after 8 hours of sleep in eyes wearing high- and low-Dk hydrogel lenses and to the contralateral control eyes. METHODS Twenty neophyte subjects wore a Lotrafilcon A (Dk, 140; Ciba Vision, Duluth GA) silicone hydrogel lens and an Etafilcon A (Dk, 18; Acuvue; Vistakon, Jacksonville, FL) 58% water content hydrogel lens of similar cent...

NaCl based solutions were applied as osmotic stress agents to alter the hydration state of the mouse eye. Full-eye responses to these osmotic challenges were monitored in vivo using a custom-built optical coherence tomography (OCT) with an extended imaging range of 12.38 mm. Dynamic changes in the mouse eye were quantified based on the OCT images using several parameters, including the central ...

The patient was referred to the Eye Clinic for a detailed ocular examination to evaluate a high-density structure found within the right globe. Pertinent history included poor vision in the right eye after being struck by a chain 7 years earlier. The left eye was normal. Visual acuity tests revealed the right eye to be aphakic. The pupil was mid-dilated and unresponsive to light, and a slit-lam...

The early development of lens opacities and lens subluxation are the most common causes of vision loss in patients with anterior megalophthalmos (AM). Cataract surgery in such patients is challenging, however, because of anatomical abnormalities. Intraocular lens dislocation is the most common postoperative complication. Patients with AM also seem to be affected by a type of vitreoretinopathy t...

Intraocular lens (IOL) is an artificial lens implanted into the eye. It usually replaces the existing crystalline lens, which is clouded over due to a cataract. In order to evaluate the optical performance of different IOLs an optomechanical model of human eye was developed. This model closely reproduces anatomical and optical properties of the average human eye. This makes it possible to measu...

This case report a rare case of 67-year-old man, presented with Marfan’s syndrome, cataract and crystalline lens dislocation of the left eye. The best corrected visual acuity (BCVA) of the left eye was 0.2. Cataract surgery was asissted by femtosecond laser LenSx. One month after surgery uncorrected visual acuity (UCVA) of the left eye was 0.9, BCVA with sph. +1.5 was 1.0. Intraocular lens have...

In a previous paper we compared eye globe records of saccadic eye movements (recorded with a scleral eye coil) with lens reflection records of the same eye movements (recorded with a dual-Purkinje-image eyetracker); we found evidence for considerable dynamic deviations between the two during and immediately after saccades. We ascribed these deviations to the movements of the eye's lens relative...

PURPOSE To evaluate the indications, lens styles, perioperative findings, and results of intraocular lens (IOL) explantation or exchange performed in the authors department in 2005. METHODS The retrospective analysis comprised 22 patients (23 eyes). Twenty-one eyes had previous phacoemulsification and IOL implantation, one eye secondary aphakic IOL, and one eye phakic IOL implantation. The in...

MALIGNANT glaucoma is a condition in which a rise in intra-ocular pressure is associated with complete or almost complete loss of the anterior chamber of the eye. It usually develops after surgical treatment for glaucoma has been carried out and in eyes with a narrow angle. It is usually found that, if it occurs in one eye, a rise in tension in the other eye follows a similar course. It is unco...