Integrins are cell surface receptors crucial for cell migration and adhesion. They are activated by interactions of the talin head domain with the membrane surface and the integrin β cytoplasmic tail. Here, we use coarse-grained molecular dynamic simulations and nuclear magnetic resonance spectroscopy to elucidate the membrane-binding surfaces of the talin head (F2-F3) domain. In particular, we...

Carter & Local [3] report acoustic data showing that in two varieties of British English, the liquids /l/ and /r/ are polarised in terms of ‘darkness’ along the F2 dimension; Leeds English has dark onset /l/ (low F2) and a light onset /r/ (high F2), and Newcastle English has the opposite pattern. Here we report data on liquid polarisation for Australian English, a variety reported to show a ver...

rH..il:ribllltlton.-tr'ee two-sample test is proposed tha t is an extension of the Wilcoxon test with arbitrary censoring on the right. The test is conditional on the pattern ~ha.t~TV:&l>ll~l..lll. The null hypothesis is H0 : F1(t) = F2(t) (t ~ T) agai nst either H1 : F1(t) < F 2(t) (t ~ T) or H2 : F1(t) < F2(t) or F1(t) > F2 (t) (t ~ T), '~here .l\,F2 are cumulative distributions (discrete or ...

A large body of evidence indicates that measurement of F2-isoprostanes, specific prostaglandin F2-like compounds derived from the non-enzymatic peroxidation of arachidonic acid, is a reliable biomarker of oxidant stress in the human body. Since the discovery of F2-isoprostanes in the early 1990s, a variety of analytical approaches has been introduced for the quantification of these novel compou...

Circulating interferon production, induced by Newcastle disease virus, is about seven times higher in C57 Black mice than in Balb/c/Gif mice. A Mendelian analysis was carried out and circulating interferon production was measured in reciprocal F1 hybrids, in the F2 generation, in progeny of backcrosses of F1 hybrids to either parent strain, and in second backcross progeny. The results indicate ...

The duration of blood feeding by similar-sized Aedes aegypti (L.) was determined under laboratory conditions in Trinidad, West Indies. Ae. aegypti from the F0 generation contained individuals that fed quickly (106.2 seconds) as well as slowly (330.0 seconds). Among the fast feeders (<2 min), the time taken for blood feeding during the first gonotrophic cycle was much shorter than that observed ...

ing from the latter exemplary viewpoint, in general we obtain a multilinear transition function f : F2 ×F2 ×F2 → F2 f (x[k+1],x[k],u[k]) = 0 = ∑ S1∈2In ∑ S2∈2In ∑ S3∈2Im δS1,S2,S3 ( ∏ j∈S1 x j[k+1] )( ∏ l∈S2 xl[k] )( ∏ m∈S3 um[k] ) , (21) with x ∈ F2 and u ∈ F2 , where the sets In = {1,2, . . . ,n}, Im = {1,2, . . . ,m} are index sets, 2In denotes the (possibly empty) power set of In and δS1,S2...

Using a panel of synthetic oligosaccharides attached to a polyacrylamide carrier, the epitope of monoclonal antibody F2, evoked to high M(r) salivary mucins, was mapped to the SO3-3Gal beta 1-3GlcNAc- moeity of the sulfo-Le(a) antigen. Using immunochemical techniques, the expression of the F2-epitope was investigated in a number of different isolated human mucin species, as well as in human and...

|f1(z)| + |f2(z)| ≥ |f(z)| ∀z ∈ D, and such, that f2 does not belong to the ideal I generated by f1, f2, i. e. f2 cannot be represented as f2 ≡ f1g1 + f2g2, g1, g2 ∈ H∞. This gives a negative answer to an old question by T. Wolff. Note, that it was well known before that under the same assumptions f belongs to the ideal if p > 2, but a counterexample can be constructed for p < 2, so our case p ...

Gliomas are the most common and lethal tumor type in the brain. The present study investigated the effect of oligomer procyanidins (F2) (F2, degree of polymerization 2-15), a natural fraction isolated from grape seeds on the biological behavior of glioblastoma cells. We found that F2 significantly inhibited the glioblastoma growth, with little cytotoxicity on normal cells, induced G2/M arrest a...