Local relapses of psoriasis involve educated T cells with the capacity to survive in skin. Inherited from previous flares, tissue-resident memory are prone produce IL-17 resolved epidermis. Their intake fatty acids through FABP5 receptor is essential for their residence and function, we thus hypothesize that surface composition could affect epidermal cell populations. In patients successfully t...

In early pregnancy, fetal skin wounds can heal quickly and undergo a transition period from scarless healing to scar formation. The aim of the present study was identify potential biomarkers associated with repair cleft lips, in order determine intrinsic factors leading formation embryonic tissue. A stable model lip established using microsurgery by constructing wedge?shaped lip?like defect rat...

Long noncoding RNAs (lncRNAs) can harbor DNA binding domains and regulate target gene expressions by to their promoter regions. Although a large proportion of differentially expressed lncRNAs have been identified in psoriatic skin, chronic inflammatory disease enriched pro-inflammatory genes, cell type specificity are yet be revealed. We performed scRNA-seq experiments non-lesional skin lesiona...

Abstract Introduction Placenta is a complex organ that plays significant role in the maintenance of pregnancy health. It dynamic undergoes dramatic changes growth and development at different stages gestation. In first-trimester, conceptus develops low oxygen environment favors organogenesis embryo cell proliferation angiogenesis placenta; later pregnancy, higher concentration required to suppo...

The potential role of liver fatty acid binding protein (L-FABP) in modulating cellular sterol distribution was examined in mouse L-cell fibroblasts transfected with cDNA encoding L-FABP. L-cells were chosen because they contain only a small amount of endogenous FABP which does not bind [3H]cholesterol, does not enhance intermembrane sterol transfer, and whose content is unaltered by the express...

On the basis of their abilities to bind bile acids and/or cholesterol, the physiological role(s) of liver fatty acid-binding protein (L-FABP) and sterol carrier protein (SCP) 2/SCP-x (SCP-2/SCP-x) gene products in biliary bile acid and cholesterol formation was examined in gene-ablated male mice. L-FABP (LKO) or L-FABP/SCP-2/SCP-x [triple-knockout (TKO)] ablation markedly decreased hepatic bile...

Intestinal enterocytes contain two homologous fatty acid-binding proteins, intestinal fatty acid-binding protein (I-FABP)2 and liver fatty acid-binding protein (L-FABP). Since the functional basis for this multiplicity is not known, the fatty acid-binding specificity of recombinant forms of both rat I-FABP and rat L-FABP was examined. A systematic comparative analysis of the 18 carbon chain len...

Liver fatty acid-binding protein (L-FABP) and liver bile acid-binding protein (L-BABP), in the liver intra-cytoplasm of chicken, are members of the fatty acid-binding protein subfamily. This study was designed to analyze and compare L-FABP and L-BABP expression levels between fat and lean lines in chicken liver tissue, and to determine the relationship between their expression and lipid metabol...