The process of single-point incremental forming (SPIF) is a relatively new technology that primarily used in the production prototypes and small quantities products. However, has several limitations with respect to quality characteristics its This study examined effects four parameters—namely, tool diameter, feed rate, step size, sheet thickness—on final product. A total 15 product responses we...

Herpes simplex virus type 1 (HSV-1) is known to cause diseases of various severities. There is increasing interest to find drug combinations to treat HSV-1 by reducing drug resistance and cytotoxicity. Drug combinations offer potentially higher efficacy and lower individual drug dosage. In this paper, we report a new application of fractional factorial designs to investigate a biological system...

The aim of the present investigation was to prepare extended release film coated matrix tablets of cephalexin using binary mixture of two grades of hydrophilic polymer, hydroxypropyl methyl cellulose (HPMC), by direct compression method. Results of the preliminary trials indicated that the polymers used have significant release retarding effect on the formulation. To study the effect of concent...

In this paper, we present an unexpected link between the Factorial Conjecture ([8]) and Furter’s Rigidity Conjecture ([13]). The Factorial Conjecture in dimension m asserts that if a polynomial f in m variables Xi over C is such that L(f) = 0 for all k ≥ 1, then f = 0, where L is the C-linear map from C[X1, · · · , Xm] to C defined by L(X l1 1 · · ·X lm m ) = l1! · · · lm!. The Rigidity Conject...

The colon is a promising site for drug targeting owing to its long transit time and mild proteolytic activity. The aim of this study was to prepare new low methoxy amidated pectin/NaCMC microspheres cross-linked by a mixture of Zn(2+) and Al(3+) ions and test their potential for colonic targeting of progesterone. A 2(4) factorial design was carried out to optimize the preparation conditions. Hi...

By studying treatment contrasts and ANOVA models, we propose a generalized minimum aberration criterion for comparing asymmetrical fractional factorial designs. The criterion is independent of the choice of treatment contrasts and thus model-free. It works for symmetrical and asymmetrical designs, regular and nonregular designs. In particular, it reduces to the minimum aberration criterion for ...

The present work is aimed at the optimization of nanosuspension of felodipine, a poorly water soluble antihypertensive drug using Full factorial Design. A 3 Full factorial design using Design Expert Version 8.0.7.1was employed to study the effect of the independent variables (diffusing drug concentration and stabilizer concentration) on the dependent variables (particle size, percentage of drug...