homogeneously staining regions (hsr) or double minute chromosomes (dmin) are autonomously replicating extra-chromosomal elements that are frequently associated with gene amplifi cation in a variety of cancers. the diagnosis of leukemia patients was based on characterization of the leukemic cells obtained from bone marrow cytogenetics. this study report two cases, one with acute myeloblastic leu...

background: numerous studies have reported prehypertension (pre-htn) as a risk factor for the cardiovascular diseases as hypertension (htn). aim: the present study aimed to evaluate the effects of pre-htn on cardiovascular incidences among the females of isfahan cohort study (ics). materials and methods: healthy female at baseline were followed for a median of 6.7 years. they were divided into ...

background: to evaluate the association of apolipoprotein b (apob), apolipoprotein a (apoa), and apob/apoa ratio with the body fat indicators in patients with stable angina pectoris (sa). materials and methods: one hundred and twenty two participants aged 40-60 years old, with a mean age of 52.1 ± 7.2 years and sa, were recruited for the present study. body weight, height, and waist circumferen...

Obstacle avoidance is a major requirement for any technological aid aimed at helping partially sighted (TAPS) people to navigate safely. In this paper, a stereo vision-based algorithm (Ground Plane Obstacle Detection) is extended to detect small obstacles for TAPS using RANSAC dynamic recalibration and Kalman Filtering. Obstacle detection and false alarm are investigated probabilistically. Furt...

Innovative clinical and translational research is often delayed or prevented by reviewers' expectations that any study performed in humans must be shown in advance to have high statistical power. This supposed requirement is not justifiable and is contradicted by the reality that increasing sample size produces diminishing marginal returns. Studies of new ideas often must start small (sometimes...

Due to the high etiological diversity and the potential for malignancy, pulmonary nodules represent a clinical challenge, becoming increasingly frequent as the number of CT examinations rises. The topic gains even more importance as clear evidence for the effectiveness of CT screening was provided by the National Lung Screening Trial (NLST). Yet, the results were tempered by the high false-posi...