A 2006 National Cancer Institute workshop on chromosomal translocations brought together laboratory, clinical, and population scientists to cross-fertilize and catalyze research on this important disease process. The deliberations revealed significant contrasts between two types of translocations that result in either deregulated expression of oncogenes or formation of novel fusion genes. The c...

background: premature ovarian failure (pof) is a disorder of multi causal etiology. autoimmunity has been proposed as a mechanism for some cases of ovarian follicle dysfunction which is evident in pof. the aim of this study was to identify the level of auto-antibodies in pof and familial pof patients. materials and methods: in this study, auto-antibodies including anti-ovarian antibody (aoa), a...

Context Conservation translocations are increasingly being used in the management of rare plants, yet have low success maintaining populations through recruitment. Aims We investigated whether survival translocated recruitment and, therefore, cost effectiveness, can be improved by selecting optimal microsites for both adults and seedlings. Methods Caladenia colorata plants propagated symbiotica...

The long-term biological effects of wear debris are unknown. We have investigated whether there is any evidence of cumulative mutagenic damage in peripheral blood lymphocytes of patients undergoing revision arthroplasty of predominantly metal-on-plastic total hip replacements compared with those at primary arthroplasty. There was a threefold increase in aneuploidy and a twofold increase in chro...

It has long been appreciated that tumor cells carry chromosomal aberrations (1). Deviation from the paired ordering of autosomes and sex chromosomes by either increasing or decreasing the copy number of a given chromosome, is referred to as aneuploidy. Errors in the faithful segregation of chromosomes during mitotic or meiotic cell division play a crucial role in the generation of chromosomal a...

Specific chromosomal changes are consistently associated with several morphologically or histologically distinct forms of cancer [1]. In a few hematolymphoid malignancies, chromosomal translocations are known to occur near or within the cytologic loci for cellular homologues of retroviral-encoded oncogenes [2]. For example, both the c-abl and c-myc proto-oncogenes are targets for interchromosom...

UNLABELLED Chromosomal translocations are common in cancer, and in some cases may be causal in the progression of the disease. Using microarrays, in which the expression of thousands of genes are simultaneously measured, could potentially allow one to detect recurrent translocations for a particular cancer type. Standard statistical tests, such as the t-test are not suited for detecting these t...