Background: Anemia and consequently low oxygen can cause changes in the function and structure of the testis and spermatogenesis, Iron released from red blood cells, followed by the increased oxidative stress, which may cause tissue iron. This study was designed to minimize the deleterious effects of hypoxia on the genitals. Materials and Methods: Eighteen mature male mice were randomly divided...

Background: Myocardial Infarction (MI) is a main cause of death and disability worldwide, whichinvolves a number of genetic, physiopathologic and socio-economic determinants. The aim of thisstudy was to assess the patterns of association between education, wealth and some other risk factorswith non-fatal MI in Tehran population.Methods: Data derived from a second round of large cross-sectional ...

BACKGROUND Suicide by self-poisoning is an important cause of death worldwide. A substantial proportion of those with a fatal outcome may come into contact with medical services before they die. AIM To estimate the proportion of self-poisoning suicides who reached hospital alive; to compare those who reached hospital alive with those who did not; to describe in detail the clinical characteris...

There are a number of conditions which can be grouped together as ARI. Many represent potentially fatal pathophysiological states that are rapidly reversible if identified and treated properly. Physiological alterations that result from the hypobaric hypoxia of altitude include cerebral vasodilatation, altered ventilatory patterns, pulmonary vasoconstriction, decreased cardiac output, and alter...

RATIONALE Pulmonary hypertension is a fatal disease; however, its pathogenesis still remains to be elucidated. Thrombin-activatable fibrinolysis inhibitor (TAFI) is synthesized by the liver and inhibits fibrinolysis. Plasma TAFI levels are significantly increased in chronic thromboembolic pulmonary hypertension (CTEPH) patients. OBJECTIVE To determine the role of activated TAFI (TAFIa) in the...

This review addresses the pathophysiology and treatment of hemorrhagic shock - a condition produced by rapid and significant loss of intravascular volume, which may lead sequentially to hemodynamic instability, decreases in oxygen delivery, decreased tissue perfusion, cellular hypoxia, organ damage, and death. Hemorrhagic shock can be rapidly fatal. The primary goals are to stop the bleeding an...

Introduction: The G-protein coupled receptor 30 (GPR30) gene is a member of the G-protein coupled receptor (GPCR) family; involved in breast, endometrial, and ovarian cancers. Many GPCR receptors that are implicated in several types of human cancers are correlated with increased cell proliferation and tumor progression; especially GPR30 gene. Methods: The breast cancer MCF-7 and MDA-MB-231 cel...

Obstructive sleep apnea (OSA) is a partial (hypo-apnea) or complete (apnea) interruption of air flow for more than 10 s during sleep. When the number of apneas-hypoapneas per hour of sleep (IAH) exceed five events, it is considered as OSA, a clinical entity. The prevalence of OSA is above 20%.1,2 OSA is deemed to be an independent cardiovascular risk factor for the development of cardiovascular...

BACKGROUND Placental insufficiency is a major cause of antepartum stillbirth and fetal growth restriction (FGR). In affected pregnancies, delivery is expedited when the risks of ongoing pregnancy outweigh those of prematurity. Current tests are unable to assess placental function and determine optimal timing for delivery. An accurate, non-invasive test that clearly defines the failing placenta ...

Abstract Background and Aims Mitophagy activation is crucial for hypoxia signaling in acute kidney injury (AKI). Selective removal of damaged mitochondria mediated through a concerted function coding non-coding RNA expressions. Insights on HIF-1α lncRNA-regulated mitophagy mechanism are not known. The study aims to investigate the role hypoxia-inducible factor 1α (HIF-1α) regulated long (lncRNA...