The influence of male sex hormones on the development of the accessory sex organs in the rat can be enhanced: (a) by esterification with certain lower fatty acids (1, 2) ; (b) by administering the hormone together with either certain higher fatty acids (3) or high molecular weight saturated primary alcohols ((3) p. 1974) ; the injection of the hormone and the second component must be made at th...

BACKGROUND Thrombolysis is conventionally regarded as dissolution of the fibrin matrix of thrombi by plasmin, but the structure of clots in vivo includes additional constituents (proteins, phospholipids) that modulate their solubilization. OBJECTIVE We examined the presence of free fatty acids in thrombi and their effects on distinct stages of fibrinolysis (plasminogen activation, plasmin act...

an 8-week feeding experiment was carried out on beluga (huso huso) juvenile to evaluate the effects of different levels of fish oil containing n-3 highly unsaturated fatty acids (n-3 hufas) on fish growth and fatty acid composition. the requirements of beluga juvenile for n-3 hufas were studied by feeding fish diets containing six different levels of n-3 hufas ranging from 1.56 to 17.25% (% of ...

Disruption of lipid and carbohydrate homeostasis is an important factor in the development of prevalent metabolic diseases such as diabetes, obesity, and atherosclerosis. Therefore, small molecules that could reduce insulin dependence and regulate dyslipidemia could have a dramatic effect on public health. The grapefruit flavonoid naringenin has been shown to normalize lipids in diabetes and hy...

  Eviscerated sea bass, Dicentrarchus labrax were irradiated by Cobalt-60 at commercial irradiation facility at dose of 2.5 and 5 kGy at 2–4°C. The influences of the irradiation on proximate, fatty acid and amino acid composition in cultured sea bass were investigated. Significant differences (P<0.0.5) were found between non-irradiated and irradiated sea bass in terms of moisture, protein, fat,...

Peroxisome proliferator-activated receptor-gamma co-activator 1alpha (PGC1alpha) is a promiscuous co-activator that plays a key role in regulating mitochondrial biogenesis and fuel homeostasis. Emergent evidence links decreased skeletal muscle PGC1alpha activity and coincident impairments in mitochondrial performance to the development of insulin resistance in humans. Here we used rodent models...

The formation of prostaglandins by prostaglandin H synthase can be limited by the availability of the fatty acid substrate or the hydroperoxide activator and also by a self-catalyzed inactivation associated with the oxygenation reaction. Each pmol of synthase appeared able to form only about 1300 pmol of prostaglandin from arachidonate before it was inactivated. This extent of synthesis was not...

CD36 is a fatty acid transporter expressed in various tissues including adipose, heart, and skeletal muscle tissues. The elevated fasting triglyceride levels,intermediate-density lipoprotein cholesterol levels, and postprandial hyperlipidemia observed in human CD36 deficiency have been suggested as being due to abnormal fatty acid metabolism and insulin resistance (1,2). Lipid abnormalities and...