Fermi coordinates (FC) are supposed to be the natural extension of Cartesian coordinates for an arbitrary moving observer in curved space-time. Since their construction cannot be done on the whole space and even not in the whole past of the observer we examine which construction principles are responsible for this effect and how they may be modified. One proposal for a modification is made and ...

We present a new hybrid constraint solving schema which retains some systematicity of constructive search while incorporating the heuristic guidance and lack of commitment to variable assignment of local search. Our method backtracks through a space of complete but possibly inconsistent solutions while supporting the freedom to move arbitrarily under heuristic guidance. The version of the schem...

Using three different Fc g receptor (Fc g R)-deficient mouse strains, we examined the induction of autoimmune hemolytic anemia by each of the four immunoglobulin (Ig)G isotype-switch variants of a 4C8 IgM antierythrocyte autoantibody and its relation to the contributions of the two Fc g R, Fc g RI, and Fc g RIII, operative in the phagocytosis of opsonized particles. We found that the four IgG i...

Inositol and tyrosine phosphatases have been implicated in inhibitory signaling by an Fc receptor for immunoglobulin G, Fc RIIB, in B cells, mast cells, and monocytes. Here, we propose a role for the Src homology 2 (SH2)-containing tyrosine phosphatase-1 (SHP-1) in Fc RIIB-mediated inhibition of Fc R signaling. Coexpression of SHP-1 enhances Fc RIIB-mediated inhibition of Fc RIIA phagocytosis i...

PURPOSE Febrile convulsion (FC) and Tourette syndrome (TS) are both common neurological disorders in infants and children. Both disorders share clinical similarities, such as paroxysmal symptoms with normal neurodevelopment and expected remission over time. This population-based study investigated the association between FC with TS during childhood neurodevelopment. METHOD We used the Taiwan ...

Nanofibers containing ferrocene (Fc) have been prepared for the first time by electrospinning. In this paper, Fc was dispersed uniformly throughout the poly(vinypyrrolidone) (PVP) matrix for the purpose of combining the properties of PVP and Fc. The effects of solvents and Fc concentration on the morphologies and diameters of nanofibers were investigated. In the DMF/ethanol solvent, the morphol...

Macrophage proliferation can be stimulated by phagocytosis and by cross-linking of Fc receptors (Fc R). In this study, we investigated the role of Fc Rand the signaling cascades that link Fc R activation to cell cycle progression. This effect was mediated by the activating Fc R, including Fc RI and III, via their Fc subunit. Further investigation revealed that the cell cycle machinery was activ...

Therapeutic monoclonal antibodies and Fc-fusion proteins are successfully used in treatment of various diseases mainly including cancer, immune disease, and viral infection, which belong to the Fc-based therapeutics. In recent years, engineered Fc-derived antibody domains have also shown potential for Fc-based therapeutics. To increase the druggability of Fc-based therapeutic candidates, many e...

Due to the long serum half-life provided by the neonatal Fc receptor (FcRn) recycling, the IgG1 Fc has been pursued as the fusion partner to develop therapeutic Fc-fusion proteins, or as the antibody-derived scaffold that could be engineered with antigen-binding capabilities. In previous studies, we engineered the monomeric Fc by mutating critical residues located on the IgG1 Fc dimerization in...