UNLABELLED Fetal susceptibility to hypoxic brain injury increases over the last third of gestation. This study examined the hypothesis that this is associated with impaired mitochondrial adaptation, as measured by more rapid oxidation of cytochrome oxidase (CytOx) during profound asphyxia. METHODS Chronically instrumented fetal sheep at 0.6, 0.7, and 0.85 gestation were subjected to either 30...

how to cite this article: chiabi a, nguefack s, mah e, nodem s, mbuagbaw l, mbonda e, tchokoteu pf, doh a. risk factors for birth asphyxia in an urban health facility in cameroon. iran j child neurol. 2013 summer; 7(3):46-54. objective the world health organization (who) estimates that 4 million children are born with asphyxia every year, of which 1 million die and an equal number survive with ...

The blanket use of prostaglandin E2 pessaries, as reported by Mr J H Shepherd and his colleagues (14 July, p 108), does concern me. While they did draw attention to the need for fetal monitoring in such patients, I wonder how satisfactorily this can be achieved, especially in relatively high-risk cases, under such circumstances and whether such monitoring could not be better achieved by direct...

BACKGROUND Obstetric complications have been regarded as a risk factor for schizophrenia later in life. One of the mechanisms underlying the association is postulated to be a hypoxic process in the brain in the offspring around the time of birth. Hippocampus is one of the brain regions implicated in the late-onset dopaminergic dysfunction associated with hypoxic obstetric complications. METHO...

It is not possible to identify all pregnancies at risk of neonatal hypoxic-ischemic encephalopathy (HIE). Many women use some form of analgesia during childbirth and some anesthetic agents have been shown to be neuroprotective when used as analgesics at subanesthetic concentrations. In this study we sought to understand the effects of two anesthetic agents with presumptive analgesic activity an...

Subcutaneous fat necrosis (SCFN) is an uncommon and yet, a benign condition seen in full term neonates who experience perinatal asphyxia and or traumatic delivery. It is temporary, self limited condition of unknown pathophysiology. Characteristic lesions are indurated, erythematous nodules or plaques over the areas prone for pressure such as back, arms, buttocks, thighs and face. This condition...

Metabolomics in maternal-fetal medicine is still an "embryonic" science. However, there is already an increasing interest in metabolome of normal and complicated pregnancies, and neonatal outcomes. Tissues used for metabolomics interrogations of pregnant women, fetuses and newborns are amniotic fluid, blood, plasma, cord blood, placenta, urine, and vaginal secretions. All published papers highl...

Syphilis remains a serious cause of neonatal morbidity and mortality worldwide. In this paper, we describe a case of congenital syphilis that was fully supported by abnormal fetal heart rate patterns and placental histopathological evidence. A 24-year-old para 4 woman, who did not attend antenatal care, was admitted to our hospital with a complaint of abdominal discomfort at an estimated 31-wee...

Babies with a normal heart and persistence of the fetal circulation are frequently referred to the cardiologist because they present with severe cyanosis in the absence of parenchymal lung disease. Persistence of the fetal circulation may be associated with birth asphyxia, polycythaemia, hypoglycaemia,l and premature closure of the ductus arteriosus.2 Occasionally, however, no "trigger" factor ...