H1-antihistamines are probably the most frequently used drugs in allergic diseases, with widely established efficacy, tolerance, and safety. We report a patient with urticaria due to ingestion of ebastine and fexofenadine. Skin prick tests, patch tests, and basophil activation tests with the implicated drugs and antihistamines from other families were negative. The oral challenges with the impl...

Background Allergic rhinitis is well known to be accompanied by inflammatory responses in the nasal wall and lumen including predominant infiltration of eosinophils, T cells and mast cells. With the discovery of IgE as the link between allergen exposure and mediator release, mast cells established their role as effector cells in the development and maintenance of allergic diseases. However, the...

Introduction: The goal of the current work is to create an RP-HPLC method for quantitative analysis Acebrophylline, Montelukast, and Fexofenadine in Pharmaceutical dosage form. Materials Methods: Chromatographic separation Montelukast was executed on Waters Alliance-e2695, by using Hyper clone 5μ BDS C18 130A (250 x 4.6mm) column mobile phase consisting Methanol: Ammonium formate adjusted pH-6 ...