Finasteride in hospitalized adult males with COVID-19: A risk factor for severity of the disease or an adjunct treatment: randomized controlled clinical trial

Finasteride, a 5-alpha reductase (5α-R) inhibitor, is widely used drug for treating androgen-dependent conditions. However, its use associated with sexual, psychological, and physical complaints, suggesting that other mechanisms, in addition to 5α-R inhibition, may be involved. Here, multidisciplinary approach has been identify potential finasteride off-target proteins. SPILLO-PBSS software sug...

A group of biologically active 4-azasteroids was studied by C-NMR spectroscopy in solution and in the solid phase. A full assignment of signals in the spectra of samples in chloroform was performed for thirteen 4-azasteroids using two-dimensional techniques. Substituent and steric effects of a nitrogen atom, and their influence on chemical shifts of the neighboring carbon atoms are discussed. C...

PURPOSE Previous studies demonstrated a negative correlation between prostate volume and biopsy yield. By decreasing prostate volume 5alpha-reductase inhibitors may enhance cancer detection, which may explain the greater detection of high grade tumors in the finasteride arm of the Prostate Cancer Prevention Trial. MATERIALS AND METHODS A mathematical model was constructed to analyze the effec...

This study demonstrated the antiproliferative potential of several dehydroepiandrosterone derivatives 2a-b, 3a-f, and 4a-f in LNCaP cells. cells were cultured presence vehicle, dihydrotestosterone, or testosterone plus 4a-f, finasteride. At 24 h 3-(4,5-dimethylthiazol-2-yl)-2,5-di phenyltetrazolium bromide-test was performed to determine cell proliferation. In addition, kinetic SRD5A1 these stu...

We describe a case of a 44-year-old woman with biopsy-proven female androgenic alopecia (FAGA), or female pattern alopecia, who was nonresponsive to topical minoxidil. After careful consideration and discussion with the patient, the decision was made to introduce oral finasteride 1.25 mg daily. After only 3.5 months of therapy there was a remarkable reduction in hair shedding and increased hair...