Seizure disorders are a major public health problem in developing country like India. Epilepsy characterized by recurrent unprovoked seizures is common heterogeneous neurological children that exerts significant medical, physical, psychological, social, and economic challenge. This study evaluated the importance of available diagnostic modalities, EEG MRI, which could influence management, prog...

Epilepsy is a common disorder of childhood occurring with an incidence in the range 46–60 out of 100,000 in the Western world. It is most common in the fi rst year of life, and declines progressively after the age of 10 years. Based on clinical and electrophysiologic fi ndings, two main forms of epilepsy are recognized: localization-related (partial) and generalized. The question of ‘when to tr...

A 39-year-old, right-handed woman had seizures for two years which were always triggered by exposure to various types of music: the first occurred while she listened to a tune she particularly liked, Con Te Partiro, by Andrea Boccelli. Other triggering factors were various types of music such as supermarket background music and polyphonic singing or instrumental music played by family members. ...

OBJECTIVES Emotional/behavioral disorders are often comorbid with childhood epilepsy, but both may be predicted by social disadvantage and fetal risk indicators (FRIs). We used data from a British birth cohort, to assess the association of epilepsy, single unprovoked seizures, and febrile seizures with the later development of emotional/behavioral problems. METHODS A total of 17,416 children ...

Benign familial neonatal convulsion is a rare autosomal dominant inherited epilepsy syndrome characterized by unprovoked seizures in the first few days of life, normal psychomotor development, and a positive intergenerational family history of neonatal seizures. Over 90% of the affected individuals have inherited causal mutations in KCNQ2, which encodes for the potassium voltage-gated channel s...

Epilepsy is a chronic neurological condition, following some trigger, transforming a normal brain to one that produces recurrent unprovoked seizures. In the search for the mechanisms that best explain the epileptogenic process, there is a growing body of evidence suggesting that the epilepsies are network level disorders. In this review, we briefly describe the concept of neuronal networks and ...

Alzheimer's disease (AD) is the most frequent cause of dementia. Besides cognitive deterioration, patients with AD are prone to seizures - more than 20% of patients diagnosed with AD experience at least one unprovoked seizure and up to 7% have recurrent seizures. Although available antiepileptic drugs (AEDs) may suppress seizures in patients with AD, they may also worsen cognitive dysfunction a...

abstract background: the efficacy of anticonvulsants after a first seizure is uncertain the more predictable the time and the type of recunent seizure, the more preventable the probable events. this study was conducted to evaluate sirnilmity of type and time of a first seizure and its recuttence in children. methods: 174 children with at least two separate seizures were taken into account. resu...

The clinical evolution of untreated epilepsy has been rarely studied in developed countries, and the existence of a distinct syndrome characterized by rarely repeated seizures (oligoepilepsy) is debated. The aim of this study is to assess the natural history of 163 untreated patients with epilepsy in order to evaluate whether oligoepilepsy retains specific features. We retrospectively evaluated...

BACKGROUND In patients with unprovoked venous thromboembolism (VTE), the optimal duration of anticoagulation is anchored on estimating the risk of disease recurrence. OBJECTIVES We aimed to develop a score that could predict the recurrence risk following a first episode of unprovoked VTE, pooling individual patient data from seven prospective studies. METHODS One thousand eight hundred and ...