PURPOSE The aim of this longitudinal study was to determine whether the depot formulation of an antipsychotic reduces violence in outpatients with schizophrenia as compared to oral administration of the same antipsychotic. METHODS Forty-six previously violent patients with schizophrenia were randomised to receive treatment with oral or depot zuclopenthixol for 1 year. Clinicians interviewed p...

This paper focuses on a modified Multi-Depot Unmanned Aerial Vehicle Routing Problem (MMDUAVRP). Comparing to classic multi-depot vehicle routing problem, our studied problem has no constraints restrict the depot where (UAV) departs and returns. work aims minimize number of UAVs total distance traveled by all UAVs. is mathematically formulated in this heuristic-assignment based hybrid large nei...

The Rental Fleet Scheduling Problem (RFSP) arises in vehicle rental operations that offer a wide variety of vehicle types to customers, and allow a rented vehicle to “migrate” to a setdown depot other than the pickup depot. When there is a shortage of vehicles of a particular type at a depot, vehicles may be relocated to that depot, or vehicles of similar types may be substituted. The RFSP invo...

The article presents a framework for the resolution of rich vehicle routing problems which are difficult to address with standard optimization techniques. We use local search on the basis on variable neighborhood search for the construction of the solutions, but embed the techniques in a flexible framework that allows the consideration of complex side constraints of the problem such as time win...

PURPOSE Peptide drugs for antineoplastic therapies usually have low oral bioavailability and short in vivo half-lives, requiring less preferred delivery methods. Lanreotide depot is a sustained-release somatostatin analog (SSA) formulation produced via an innovative peptide self-assembly method. Lanreotide is approved in the USA and Europe to improve progression-free survival (PFS) in patients ...

Six patients who had experienced prolonged steroid-induced pituitary-adrenal suppression were treated with 100 U of depot procine ACTH every 2 to 4 days for several months. Such treatment did not hasten the recovery of normal pituitary-adrenal function compared with the rate of recovery of a group of similarly suppressed patients who received no depot ACTH. Eight of nine patients who received p...

Generally, progestogens, i.e. progesterone in combination with oestradiol esters, are used primarily in the treatment of menstrual irregularities to maintain endangered pregnancies. Their derivatives are orally active medroxyprogesterone acetate including hydroxyprogesterone caproate, chlormadinone acetate, megestrol acetate. Naturally occurring glucocorticoids are often used in medicine such a...

UNLABELLED Ligand Depot is an integrated data resource for finding information about small molecules bound to proteins and nucleic acids. The initial release (version 1.0, November, 2003) focuses on providing chemical and structural information for small molecules found as part of the structures deposited in the Protein Data Bank. Ligand Depot accepts keyword-based queries and also provides a g...

pituitary suppression by depot gnrh agonist may be excessive for ovarian stimulation. this study compares the efficacy of a single half-dose depot triptorelin and reduced-dose daily buserelin in a long protocol icsi/et. methods: a total of 182 patients were randomized into two groups using sealed envelopes. pituitary desensitization was obtained in group 1 (91 patients) with half-dose (1.87 mg)...

introduction: safety culture is a set of beliefs, norms, incentives, social and technical roles and functions that make the core of the safety management system. the aim of this study was to examine factors affecting safety culture and its relationship to accident in the oil depots. methods: case-control study was conducted in 2016. 300 employees of 3 oil depot in tehran were selected that 150 ...