objective(s): the aim of study was to investigate the antinociceptive effect of intracerebroventricular (icv) microinjection of origanum vulgare (org) extract and possible involvement of opioid receptors.   materials and methods: cannula was inserted into left ventricle of male rats. five days after surgery tail flick latency (tfl) was measured after icv microinjection of, org (1, 3 and 6 μg / ...

Ligustrum robustum is an indigenous medicinal shrub that belongs to the family, Oleaceae. It is a major component of Chinese tea, Ku-Ding-Cha, which is used to prevent common cold, rhinitis, itching eyes, and headache. The present study was undertaken to evaluate the anti-inflammatory and analgesic activities of the aqueous extract of Ligustrum robustum (ALR) in experimental animal models. ALR ...

In the traditional medicine, Taxus baccata Linn. has been used as analgesic, anticonvulsant, and antiinflammatory remedy. In the present study, bark of plant was extracted with 95% ethanol and ether at room temperature and evaluate for their analgesic activity in mice using the tail-flick and acetic acid-induced writhing method. Ether extract exhibits potent analgesic activity in tail-flick tes...

Studies have shown that noxious cutaneous stimulation engages physiologically different antinociceptive systems to inhibit a spinal reflex, tail withdrawal from radiant heat. Two experiments are reported that examine the relationship between the inhibition of the tail-flick response and brain-mediated responses to nociception. The induction of a spinally mediated antinociception was accompanied...

Objective: The present study was aimed to find out the central and peripheral analgesic activity of aqueous leaf extract of Solanum melongena Linn (AESML) in experimental animals. Methods: Preliminary phytochemical analysis of AESML was performed by chemical tests. The central analgesic activity was measured by tail flick method in Wistar rats and peripheral analgesic activity was measured by a...

Beta-endorphin (fS-EP) is a 31 amino acid polypeptide secreted by the pituitary, brain, and various other tissues. it has potent opiate-like activity, can produce analgesia, and may play a physiological role in adapting the immune system to stress by affecting Iymphocyte and complement binding activity. To investigate the effect of fS-EPon pain threshold, we analyzed cerebrospinal fluid (CSF) a...

Kick out the reticulons to close the envelope The nuclear envelope reforms when tube-forming reticulons are ejected from chromatin-associated ER tubules, say Anderson and Hetzer. The nuclear envelope was once thought to disintegrate into vesicles during mitosis, but growing evidence suggests it is absorbed into the endoplasmic reticulum. Recent in vitro experiments by these authors have shown t...

OBJECTIVE S-Adenosylmethionine (SAMe) is a major methyl donor in the brain and is also an antidepressant with few reported side effects; however, SAMe is relatively expensive and unstable. Brain SAMe can be increased by giving methionine to rats, raising the possibility that methionine may be an antidepressant. We aimed to study whether SAMe and methionine, when given orally to rats, could rais...