FLIP is a well-established suppressor of death receptor-mediated apoptosis. To define its essential in vivo role in myeloid cells, we generated and characterized mice with Flip conditionally deleted in the myeloid lineage. Myeloid specific Flip-deficient mice exhibited growth retardation, premature death, and splenomegaly with altered architecture and extramedullary hematopoiesis. They also dis...

FLIP is a well-established suppressor of death receptor-mediated apoptosis. To define its essential in vivo role in myeloid cells, we generated and characterized mice with Flip conditionally deleted in the myeloid lineage. Myeloid specific Flip-deficient mice exhibited growth retardation, premature death, and splenomegaly with altered architecture and extramedullary hematopoiesis. They also dis...

This paper describes a semi-dynamic CMOS flip-flop family featuring embedded Threshold Logic functions. First, we present the concept of flip-flop featuring embedded Threshold Logic, and then we describe the circuit and its operation. Subsequently, we present the design issues and the experimental results of such Threshold Logic flip-flops, obtained in 0.25pm CMOS technology. It is shown in thi...

Flip Flops are critical timing elements in digital systems which has large impact on circuit speed and power consumption. The performance of flip flop is an important parameter to determine performance of whole synchronous circuit. In this paper, comparison of existing flip flops with different parameters is calculated. A new design a low power pulse triggered flip-flop (FF) has been proposed h...

There is no theoretical reason to think that the spin-flip component of the Pomeron is zero. One can measure the spin-flip part using Coulomb-nuclear interference (CNI). Perturbative QCD calculations show that the spin-flip component is sensitive to the smallest quark separation in the proton, while the non-flip part probes the largest separation. According to HERA results on the proton structu...

TNF-related apoptosis-inducing ligand (TRAIL) is a tumor-selective cytokine with potential anticancer activity and is currently under clinical testing. Head and neck squamous cell carcinoma (HNSCC), like other cancer types, exhibits varied sensitivity to TRAIL. MLN4924 is a newly developed investigational small molecule inhibitor of NEDD8-activating enzyme with potent anticancer activity. This ...

Introduction Flip Chip packaging has seen an explosive growth in recent years. Over one billion devices a year are now assembled using flip chip technology. The majority are low lead count devices such as liquid crystal display drivers, watch modules, smart cards, and RFID tags. Recently the trend for higher I/O devices is to turn to flip chip in package (FCIP) as a packaging solution, which is...

Several methods of flip angle mapping for magnetic resonance imaging have been proposed. We evaluated the accuracy of five methods of flip angle measurement in the presence of measurement noise. Our analysis was performed in a closed form by propagation of probability density functions (PDFs). The flip angle mapping methods compared were (1) the phase-sensitive method, (2) the dual-angle method...

BACKGROUND AND PURPOSE Compared with MR imaging at 1.5T T1-weighted spin-echo imaging at 3T shows up with reduced gray-to-white matter contrast. The purpose of the present study was to show the effects of alterations of different flip angles as an easily accessible parameter to increase gray-to-white matter contrast. METHODS Spin-echo T1 sequences of 6 healthy volunteers were acquired in a 3T...

Inhibition of BET bromodomains (BRDs) has emerged as a promising cancer therapeutic strategy. Accordingly, inhibitors of BRDs such as JQ1 have been actively developed and some have reached clinical testing. However, the mechanisms by which this group of inhibitors exerts their anticancer activity, including induction of apoptosis, have not been fully elucidated. This report reveals a previously...