This study investigated the sensitivity of static planning of intensity-modulated beams (IMBs) to intrafraction deformable organ motion and assessed whether smoothing of the IMBs at the treatment-planning stage can reduce this sensitivity. The study was performed with a 4D computed tomography (CT) data set for an IMRT treatment of a patient with liver cancer. Fluence profiles obtained from inve...

PURPOSE To develop a comprehensive end-to-end test for Varian's TrueBeam linear accelerator for head and neck IMRT using a custom phantom designed to utilize multiple dosimetry devices. PURPOSE To commission a multiple-source Monte Carlo model of Elekta linear accelerator beams of nominal energies 6MV and 10MV. METHODS A three source, Monte Carlo model of Elekta 6 and 10MV therapeutic x-ray...

BACKGROUND Comparing initial 45 Gy of pelvic intensity-modulated radiation therapy (IMRT) and non-IMRT in terms of the late toxicities associated with advanced cervical cancer that has also been treated with definitive concurrent chemoradiotherapy and high-dose rate intracavitary brachytherapy (HDRICB). PATIENTS AND METHODS This retrospective study included 320 stage IB2-IIIB cervical cancer ...

This study compared the dosimetric performance of (a) volumetric modulated arc therapy (VMAT) with standard optimization (STD) and (b) multi-criteria optimization (MCO) to (c) intensity modulated radiation therapy (IMRT) with MCO for hippocampal avoidance whole brain radiation therapy (HA-WBRT) in RayStation treatment planning system (TPS). Ten HA-WBRT patients previously treated with MCO-IMRT ...

PURPOSE Radiation pneumonitis (RP) has been a challenging obstacle in treating stage III lung cancer patients. Beam angle optimization (BAO) technique for Tomotherapy was developed to reduce the normal lung dose for stage III non-small cell lung cancer (NSCLC). Comparative analyses on plan quality by 3 different Intensity-modulated radiation therapy (IMRT) methods with BAO were done. MATERIAL...

PURPOSE The purpose of this study is to compare the dosimetric differences among volumetric modulated arc therapy (VMAT), fixed-field intensity modulated radiotherapy (IMRT) and three-dimensional conformal radiotherapy (3D-CRT) for the preoperative locally advanced rectal cancer (LARC). METHODS Ten LARC patients treated in our department using the simultaneous escalate strategy were retrospec...

The purpose of this study is to examine plan quality, treatment planning time, and estimated treatment delivery time for 5- and 9-field sliding window IMRT, single and dual arc RapidArc, and tomotherapy. For four phantoms, 5- and 9-field IMRT, single and dual arc RapidArc and tomotherapy plans were created. Plans were evaluated based on the ability to meet dose-volume constraints, dose homogene...

The widespread adoption of on-board volumetric imaging in cancer radiotherapy has stimulated research efforts to develop online adaptive radiotherapy techniques to handle the inter-fraction variation of the patient's geometry. Such efforts face major technical challenges to perform treatment planning in real time. To overcome this challenge, we are developing a supercomputing online re-planning...

This study experimentally demonstrated a feed-forward inversion control scheme for maintaining an optimum incident irradiance on photobioreactors (PBRs) during batch cultivation. A data-based modelfree optimization using quadratic fit was utilized to rapidly estimate the optimum average fluence rate set point value that rendered maximum microalgae growth rate. Then, the feed-forward inversion c...

introduction intensity-modulated radiotherapy (imrt) is becoming an increasingly routine treatment method. imrt can be delivered by use of conventional multileaf collimators (mlcs) and/or physical compensators. one of the most important factors in selecting an appropriate imrt technique is integral dose. integral dose is equal to the mean energy deposited in the total irradiated volume of the p...