The selective serotonin reuptake inhibitor fluoxetine modifies social behavior in a number of species, including humans. Because the neural substrates for social behavior in prairie voles are sexually dimorphic, we tested whether the effects of fluoxetine on these behaviors differ by sex. Parental and pair-bonded voles were chronically treated with fluoxetine or saline and subsequently tested f...

The voltage-gated Nav1.5 channel is essential for the propagation of action potentials in the heart. Malfunctions of this channel are known to cause hereditary diseases. It is a prime target for class 1 antiarrhythmic drugs and a number of antidepressants. Our study investigated the Nav1.5 blocking properties of fluoxetine, a selective serotonin reuptake inhibitor. Nav1.5 channels were expresse...

BACKGROUND Generalized anxiety disorder (GAD) is a prevalent, disabling disease and is highly comorbid with other psychiatric disorders both in Western countries and the People's Republic of China. Fluoxetine, a selective inhibitor of serotonin reuptake (SSRI), is widely utilized in the management of GAD in clinical practice despite the lack of strong evidence. This article reviews fluoxetine t...

Hypersecretion of cortisol occurs in numerous patients with major depression and normalizes with clinical recovery during the course of chronic antidepressant treatment. These clinical data suggest that investigation of the effects of antidepressant treatments on the regulation of the brain-pituitary-adrenal axis may assist in elucidating the therapeutic basis of antidepressant actions. In the ...

this study was carried out to investigate the interaction of simultaneous use of fluoxetine (flx), a selective serotonin reuptake inhibitor, and diclofenac (dcf), a nonsteroidal anti-inflammatory drug, on food intake in goldfish, carassius auratus . treatments with different dosage of flx including control, 0, 1, and 10  µg/g body weight (bw) were injected in the fish with mean weight of 30.16 ±...

Despite the use of fluoxetine as a first-line therapy, some patients do not show good therapeutic effect. Effective antidepressant therapy will reverse low serotonin and BDNF levels found in depression. Mozart K. 448 was reported to yield effect for Based on findings, combination depression is very rare. Therefore, this study aimed determine combined hippocampal an animal model under CUMS condi...

Reduced levels of brain-derived neurotrophic factor (BDNF) in the hippocampus have been implicated in human affective disorders and behavioral stress responses. The current studies examined the role of BDNF in the behavioral consequences of inescapable stress, or learned helplessness. Inescapable stress decreased BDNF mRNA and protein in the hippocampus of sedentary rats. Rats allowed voluntary...

OBJECTIVES To evaluate the effects of antidepressants and pilocarpine on the quantity of myoepithelial cells and on the proliferation index of the epithelial cells of rat parotid glands. INTRODUCTION Hyposalivation, xerostomia, and alterations in saliva composition are important clinical side effects related to the use of antidepressants. METHODS Ninety male Wistar rats were allocated to ni...

Various studies suggest that selective serotonin reuptake inhibitors (SSRIs) may be useful in treating pathologic skin-picking. The authors investigated the effectiveness of fluoxetine in treating this behavior. Fifteen subjects with clinically significant skin-picking were recruited by newspaper advertisement. They received 6 weeks of open-label treatment with fluoxetine. Responders were then ...

fluoxetine is a common antidepressant which selectively inhibits serotonin reuptake at synaptic level. some research findings have proposed the effect this drug on neurogenesis, neuronal survival as well as proliferation of the neural progenitor cells. endometrium is a part of uterus which harbors mesenchymal stem cells. this source of stem cells can be differentiated into neural cells which ma...