Among antiserotonergic second generation antipsychotics (SGA), particularly treatment with clozapine (CLZ) is associated with the development of second-onset obsessive compulsive symptoms (OCS) in schizophrenia. However, less is known regarding the factors that increase the individual susceptibility for the development of SGA-associated second-onset OCS in schizophrenia. Here we present the cas...

Treatment of the paraphilic disorders using behavioral, cognitive, pharmacological, and social interventions has been shown to have limited success with poorly motivated or noncompliant patients. Researchers have speculated on the role of the serotonergic system in the paraphilic disorders. Recent anecdotal studies have reported successful results with the selective serotonin reuptake inhibitor...


 For antipsychotic-related sexual dysfunction, 1 guideline recommends switching to aripiprazole or another non-hyperprolactinemic antipsychotic as the first option. Alternatively, adjunctive treatment with aripiprazole, antipsychotics that have less impact on function. Another adding estrogen testosterone medication assist dysfunction in women.
 antidepressant-related agomelatine a n...

roles in several psychiatric disorders, including depression and anxiety. Obsessive compulsive disorder (OCD) is classified as an anxiety disorder characterized by obsession or compulsion. The burying of harmless objects like marbles by mice may reflect the formation of compulsive behavior. Marble burying behavior in mice is recognized as an animal model for OCD. It has been reported that marbl...