Nonoperative management of focal nodular hyperplasia (FNH) is an accepted paradigm in adults, but current management strategies for children vary substantially between institutions. We reviewed medical records at Johns Hopkins Hospital between January 1, 1998, and December 31, 2008, to investigate the diagnosis, treatment, and outcome of pediatric patients with a pathologic diagnosis of FNH to ...

A patient with microscopic metastatic renal cell carcinoma within liver focal nodular hyperplasia (FNH) is reported here. The initial CT scan was classic for liver FNH yet the following liver resection showed a microscopic metastatic renal cell carcinoma (0.48 cm) within the liver nodule. FNH in a patient with existing primary tumor probably warrants further investigation as the coexistence of ...

Focal nodular hyperplasia (FNH) is a hepatic disease first described in 1958. The existence of an accessible and minimally invasive imagistic investigation to establish the diagnosis in a large number of cases would be desirable, especially because once diagnosed, the disease needs no treatment. We present the case of a young woman with long term use of oral contraceptives in which the diagnosi...

This trial was designed to study the subchronic effects of carbon tetrachloride (CCl4) and N-Nitrosomethylurea (NMU) independently as well as in combination. In the CCl4 and CCl4 + NMU groups, the lipid peroxidation (LPO) recorded the peak level on the 15th day while in NMU group it was reached only on the 75th day. Serum gamma glutamyl transpeptidase (GGT) levels were higher on the 15th day in...

Focal epithelial hyperplasia (FEH), or Heck's disease, is a rare disease of the oral mucosa associated with infection by some subtypes of human papilloma virus, especially subtypes 13 or 32. The disease is predominantly found in children and adolescents with indigenous heritage, but other ethnic groups can be affected worldwide. To the best of the authors' knowledge, it has not been reported in...

BACKGROUND Focal nodular hyperplasia (FNH) of the liver is a benign hepatic lesion relatively common in women. No studies specifically designed to describe the presentation and imaging findings in males have been published. AIMS The aims of this study were: (a) to describe the clinical and imaging findings in 18 men with FNH, and (b) to compare these data with those observed in 216 women with...

A 30-year-old woman presented with hepatomegaly and an audible hepatic bruit at 24 weeks gestation. Non-contrast MRI demonstrated an exophytic 12.6 x 7.8 x 12.8 cm mass arising from the right lobe of the liver with a central scar, suggestive of focal nodular hyperplasia (FNH). Conservative management included monthly abdominal ultrasound examinations until the time of delivery, to assess growth...