The process by which the brain transitions into an epileptic seizure is unknown. In this study, we investigated whether the transition to seizure is associated with changes in brain dynamics detectable in the wideband EEG, and whether differences exist across underlying pathologies. Depth electrode ictal EEG recordings from 40 consecutive patients with pharmacoresistant lesional focal epilepsy ...

Adult patients with new onset of seizures are often studied by computed tomography (CT) to exclude infarct, neoplasm, vascular malformations, infection, or other pathology as a cause of their convulsion. Previous reports of cerebral angiography and radioisotope scanning in postictal patients with no obvious underlying pathology have demonstrated transient hyperperfusion or blood-brain barrier d...

Here we present a unique, but important seizure variant directly related to placement of subdural grids. Two distinct epileptogenic zones were identified, one which correlated with the patient's baseline seizures and a separate zone associated with atypical semiology and localization. Inspection of this zone at surgery revealed cortical deformation from the grid itself. The patient underwent su...

99mTC (single photon emission computed tomography) (HMPAO SPECT) was carried out during 16 frontal-lobe seizures in 15 patients. Focal changes in regional cerebral blood flow were seen during all seizures. In 9 of 16 seizures SPECT showed hyperperfusion localized to one frontal lobe. In 1 of 16 seizures ictal hypoperfusion was seen in one frontal lobe. In 2 of 16 seizures there was hyperperfusi...

Most intellectually normal children with focal epilepsy have partial complex or focal with secondary generalization seizures without a precise epilepsy syndrome. Their long-term outcome is largely unknown. Cases were identified from the population-based Nova Scotia Childhood Epilepsy cohort. Those eligible had seizure onset at 1 month to 16 years between 1977 and 1985, normal intelligence, ≥10 ...

OBJECTIVE Posttraumatic epilepsy (PTE) accounts for 20% of acquired epilepsies. Experimental models are important for studying epileptogenesis. We previously reported that repetitive high-frequency oscillations with spikes (rHFOSs) occur early after lateral fluid percussion injury (FPI) and may be a biomarker for PTE. The objective of this study was to use multiple electrodes in rat hippocampal...

Psychogenic non-epileptic seizures can co-exist with epileptic seizures. Differentiating between the two is central to appropriate management. We report the case of a patient with established focal epilepsy who developed psychogenic non-epileptic seizures in direct response to second-person auditory hallucinations. To our knowledge, this is the first description of such an occurrence. These non...

INTRODUCTION Continuous EEG (cEEG) is of great interest in view of the reported high prevalence of non-convulsive seizures on intensive care units (ICUs). Here, we describe our experiences applying a seizure warning system using cEEG monitoring. METHODS Fifty comatose ICU patients were included prospectively and monitored. Twenty-eight patients had post-anoxic encephalopathy (PAE) and 22 had ...

Rasmussen Encephalitis is a rare, immune mediated disease characterized by refractory seizures, progressive neurological dysfunction and unilateral hemispheric atrophy. This disorder typically involves single cerebral hemisphere, affecting mainly children adolescents. We report case of in young girl who was admitted with complaints recurrent focal motor seizures involving right upper lower limb...

Two women aged 21 and 19 years presented with lesional drug-resistant temporal lobe epilepsy (TLE) (table) focal impaired awareness seizures (FIAs) (figure). Inpatient video EEG monitoring captured habitual FIAs accompanied by predominant ipsilateral upper extremity automatisms that mimicked a conductor leading an orchestra (video).