Background and Objective: Recent studies have shown a relationship between energy regulation and the circadian rhythm at behavioral, molecular, and physiological levels. The present study investigated the effect of chronotype on meal timing and obesity in Iranian housewives. Materials and Methods: This cross-sectional study was carried out using a convenience-sampling method through the partic...

Cerulenin, a natural fatty acid synthase (FAS) inhibitor, and its synthetic analog C75 are hypothesized to alter the metabolism of neurons in the hypothalamus that regulate ingestive behavior to cause a profound decrease of food intake and an increase in metabolic rate, leading to body weight loss. The bulk of data exclusively originates from mammals (rodents); however, such effects are current...

OBJECTIVE Central cholinergic neural circuits play a role in the regulation of feeding behavior. The dorsomedial hypothalamus (DMH) is considered the appetite-stimulating center and contains cholinergic neurons. Here, we study the role of DMH cholinergic neurons in the control of food intake. METHODS To selectively stimulate DMH cholinergic neurons, we expressed stimulatory designer receptors...

objective: achillea millefolium (a. millefolium) is known as an orexigenic herb in iranian traditional medicine. in this study, the possible orexigenic effect of hydro-alcoholic extract of a. millefolium was investigated by measuring plasma ghrelin level.materials and methods: thirty male wistar rats were divided into five groups. control group received water. treatment groups received 50, 100 ...

dietary knowledge and access to resources are critical to improve health and nutritional status in a sustainable way. the present study was conducted to assess the dietary pattern and associated intake of different essential nutrients and vitamins by adolescents in himachal pradesh of india. a sample of 150 adolescents in the age group of 11-19 years from the two selected blocks (panchrukhi and...

Growing evidence suggests that a complex relationship exists between the central nervous system and peripheral organs involved in energy homeostasis. It consists in the balance between food intake and energy expenditure and includes the regulation of nutrient levels in storage organs, as well as in blood, in particular blood glucose. Therefore, food intake, energy expenditure, and glucose homeo...

Our past microdialysis studies in ventromedial hypothalamic nucleus (VMN) and lateral hypothalamic area (LHA) of changes in dopamine concentrations in response to changes in food intake [characterized as feeding pattern (changes in meal number and size)] in anorexia of cancer show abnormal presynaptic dopaminergic neurotransmission. To determine postsynaptic receptor status, studies were done i...

Nucleus accumbens is proposed as one of the centers in the neural circuitry involved in the regulation of feeding and drinking behaviour in rats. Injection of dopamine and angiotensin-II into this nucleus has been documented to affect water and food intake in rats. Reports on the effect of intracerebral injection of catecholamines on feeding and drinking behaviour in animal models are conflicti...

Ghrelin, a gut-brain peptide, is best known for its role in the stimulation of feeding and growth hormone release. In the brain, orexin, neuropeptide Y (NPY), and ghrelin are parts of a food intake regulatory circuit. Orexin and NPY are also implicated in maintaining wakefulness. Previous experiments in our laboratory revealed that intracerebroventricular injections of ghrelin induce wakefulnes...

Ingestion of food affects secretion of hormones from enteroendocrine cells located in the gastrointestinal mucosa. These hormones are involved in the regulation of various gastrointestinal functions including the control of food intake. One cell in the stomach, the X/A-like has received much attention over the past years due to the production of ghrelin. Until now, ghrelin is the only known ore...