(-)-gephyrotoxin-223 was formally synthesized from chiral synthon 1 which has been chemoenzymatically synthesized  in the presence  of candida antartica lipase.

We introduce the notion of formally self-adjoint conformally covariant polydifferential operators and give some constructions families such operators. In one direction, we show that any homogeneous variational scalar Riemannian invariant (CVI) induces these another use ambient metric to alternative certain produced this way, which is a self-adjoint, fourth-order, tridifferential operator should...