Gliclazide (G) is an antidiabetic drug commonly used in type 2 diabetes. It has extrapancreatic hypoglycemic effects, which makes it a good candidate in type 1 diabetes (T1D). In previous studies, we have shown that a gliclazide-bile acid mixture exerted a hypoglycemic effect in a rat model of T1D. We have also shown that a gliclazide-deoxycholic acid (G-DCA) mixture resulted in better G permea...

The pharmacist, both in community and hospital pharmacy practice, is often challenged with the preparation of a liquid dosage form not available commercially for paediatric patients, those adults unable to swallow tablets or capsules and patients who must receive medications via nasogastric or gastrostomy tubes. Recognising the lack of information available to healthcare professionals, a genera...

The aim of this study was to prepare orally disintegrating tablets (ODTs) containingdexamethasone (DEX) by direct compression method with sufficient hardness and rapiddisintegration time. In order to save time, money, and human resources in designing andimprovement of formulation, the statistical software Design Expert is used. Box–Behnkenresponse surface methodology was applied to evaluate and...

Introduction Most commercially-available dry powder inhaler (DPI) formulations utilize a carrier-based formulation concept. Utilizing a mixing process, micronized active pharmaceutical ingredient (API) particles are attached to the surface of larger excipient particles. Multiple studies list excipients such as mannitol, glucose monohydrate, trehalose, dextrose, maltose, sorbitol and maltitol fo...

A simple UV spectrophotometric method for the analysis of Amlodipine Besylate was developed to analyze the drug in bulk and in tablet formulation. In this method the simple UV spectrum of Amlodipine Besylate in aqueous ethanol (30% v/v) was obtained which exhibits absorption maxima (λ max) at 239.40 nm. The Beers law ranges was followed in the concentration range of 5-60 μg/ml. The proposed met...

This study describes a systemic approach for the formulation and evaluation of Efavirenz tablets has been done in this work using Moringa Oleifera as natural polymer at different concentrations. In order to identify medication, melting point, solubility, FTIR analysis were used. DSC was used investigating drug interactions. Consequently, no interaction between medicine detected. The formulation...

The drug candidates coming from combinatorial chemistry research and/or the drugs selected from biologically based high-throughput screening are quite often very lipophilic, as these drug candidates exert their pharmacological action at or in biological membranes or membrane-associated proteins. This challenges drug delivery institutions in industry or academia to develop carrier systems for th...

In the course of research and development of a new pharmaceutical formulation of azelaic acid in the liposomal form, we developed a rapid and accurate method for the detection of impurities using high-performance liquid chromatography. A chromatographic column from Merck (Purospher Star RP C18, 250-4 mm (5 μm) was used in the assay, and the mobile phase gradient consisted of three phases: A--me...

A simple, selective, precise and stability-indicating high-performance thin layer chromatographic method of analysis of meloxicam both as a bulk drug and in formulation has been developed. The mobile phase selected was ethyl acetate:cyclohexane:glacial acetic acid (6.5:3.5:0.02% v/v/v). The calibration curve of the drug was linear in the range of 100-500 ng. The spectrodensitometric analysis wa...

Submit Manuscript | http://medcraveonline.com J Anal Pharm Res 2015, 1(1): 00001 in terms of dissolution but the non-traditional formulation approaches can lead to a significant increase in dissolution and solubility particularly required for drugs applied in medium to higher dosages [3]. Such dosages’ requirements go along with the necessity to evaluate other formulation technologies for enhan...